家庭式经颅直流电刺激是一种治疗抑郁症的可行干预措施：一项观察性队列研究。
Home-administered transcranial direct current stimulation is a feasible intervention for depression: an observational cohort study.
作者信息
Charvet Leigh, George Allan, Charlson Erik, Lustberg Matthew, Vogel-Eyny Amy, Eilam-Stock Tehila, Cho Hyein, Best Pamela, Fernandez Luis, Datta Abhishek, Bikson Marom, Nazim Kamran, Pilloni Giuseppina
机构信息
Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States.
The Arthur S. Abramson Department of Rehabilitation Medicine, Albert Einstein College of Medicine, New York, NY, United States.
出版信息
Front Psychiatry. 2023 Aug 22;14:1199773. doi: 10.3389/fpsyt.2023.1199773. eCollection 2023.
Transcranial direct current stimulation (tDCS) is an emerging treatment for major depression. We recruited participants with moderate-to-severe major depressive episodes for an observational clinical trial using Soterix Medical's tDCS telehealth platform as a standard of care. The acute intervention consisted of 28 sessions (5 sessions/week, 6 weeks) of the left anodal dorsolateral prefrontal cortex (DLPFC) tDCS (2.0 mA × 30 min) followed by a tapering phase of weekly sessions for 4 weeks (weeks 7-10). The = 16 completing participants had a significant reduction in depressive symptoms by week 2 of treatment [Montgomery-Åsberg Depression Rating Scale (MADRS), : 28.00 ± 4.35 vs. 17.12 ± 5.32, < 0.001] with continual improvement across each biweekly timepoint. Acute intervention responder and remission rates were 75 and 63% and 88 and 81% following the taper period (week 10).
经颅直流电刺激（tDCS）是一种新兴的重度抑郁症治疗方法。我们招募了患有中度至重度重度抑郁发作的参与者，使用Soterix Medical的tDCS远程医疗平台作为标准治疗方案进行一项观察性临床试验。急性干预包括对左侧阳极背外侧前额叶皮质（DLPFC）进行28次tDCS治疗（每周5次，共6周）（2.0毫安×30分钟），随后是为期4周（第7 - 10周）的每周递减治疗阶段。16名完成试验的参与者在治疗第2周时抑郁症状显著减轻[蒙哥马利-奥斯伯格抑郁量表（MADRS），均值：28.00±4.35对17.12±5.32，P<0.001]，并且在每个双周时间点都持续改善。急性干预的有效率和缓解率在递减期（第10周）分别为75%和63%，以及88%和81%。
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