Keshani Forooz, Mahmoodi Alireza, Gholami Masood, Azmoudeh Faezeh
Department of Oral and Maxillofacial Pathology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Oral and Maxillofacial Pathology, Students Research Committee, School of Dentistry Qazvin University of Medical Sciences, Qazvin, Iran.
Dent Res J (Isfahan). 2023 Jul 25;20:81. eCollection 2023.
Recently, the role of biochemical factors in the etiology of oral squamous cell carcinoma (OSCC) has attracted some attention. Serum levels of biochemical factors may change in cancer patients. This study aimed to assess the serum level of folate, Vitamin B12, homocysteine, iron, copper, and selenium in patients with OSCC.
This descriptive analytical study was conducted on 30 primary OSCC patients (15 males and 15 females) presenting to Imam Khomeini Cancer Institute, who had not yet undergone treatment. Blood samples were taken and serum levels of folate, Vitamin B12, homocysteine, iron, copper, and selenium were measured. Serum levels of micronutrients in patients with different tumor sizes were analyzed by one-way ANOVA. Serum levels of micronutrients were compared among groups with and without metastasis and lymph node involvement using Student's -test ( < 0.05).
Serum levels of B12, folic acid, homocysteine, copper, iron, and selenium were 232.5 ± 102.68, 8.66 ± 4.06, 18.87 ± 8.81, 96.0 ± 22.64, 55.27 ± 40.58, and 92.47 ± 18.83 ng/mL, respectively. Relatively similar values were measured in patients with different tumor sizes with and without lymph node involvement and presence or absence distant metastasis. However, the serum level of folic acid in OSCC patients without lymph node involvement was significantly higher than that in OSCC patients with lymph node involvement ( < 0.05).
Despite some variations, serum levels of micronutrients in OSCC patients were within the normal limits. Considering the variations in serum level of copper in OSCC patients, it may be used as a diagnostic marker. However, further studies are warranted in this respect.
最近，生化因素在口腔鳞状细胞癌（OSCC）病因学中的作用引起了一些关注。癌症患者血清中的生化因素水平可能会发生变化。本研究旨在评估OSCC患者血清中叶酸、维生素B12、同型半胱氨酸、铁、铜和硒的水平。
本描述性分析研究对30例尚未接受治疗的原发性OSCC患者（15例男性和15例女性）进行，这些患者前往伊玛目霍梅尼癌症研究所就诊。采集血样并测量血清中叶酸、维生素B12、同型半胱氨酸、铁、铜和硒的水平。采用单因素方差分析分析不同肿瘤大小患者的血清微量营养素水平。使用Student's -检验比较有无转移和淋巴结受累组之间的血清微量营养素水平（<0.05）。
血清中B12、叶酸、同型半胱氨酸、铜、铁和硒的水平分别为±102.68、±4.06、±8.81、±22.64、±40.58和±18.83 ng/mL。在有无淋巴结受累及有无远处转移的不同肿瘤大小患者中测得的数值相对相似。然而，无淋巴结受累的OSCC患者血清叶酸水平显著高于有淋巴结受累的OSCC患者（<0.05）。
尽管存在一些差异，但OSCC患者血清微量营养素水平仍在正常范围内。考虑到OSCC患者血清铜水平的差异，它可能用作诊断标志物。然而，在这方面还需要进一步研究。
