通过血清变化筛查口腔鳞状细胞癌：一项系统评价和荟萃分析。
Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis.
作者信息
Keshani Forooz, Khalesi Saeedeh, Aghaz Alireza, Farhang Mohammadreza, Akbari Nabiollah
机构信息
Department of Oral and Maxillofacial Pathology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Oral and Maxillofacial Pathology, Dental Materials Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Dent Res J (Isfahan). 2021 Oct 21;18:88. eCollection 2021.
BACKGROUND
Oral squamous cell carcinoma (OSCC) is the sixth common cancer in the world and 90% of oral malignant tumors. The aim of this study was the investigation of changes in some metabolic elements of OSCC patients' serum.
MATERIALS AND METHODS
In this study, international databases such as PubMed, Science Direct, Scopus, Web of Science, and National (Magiran, IranMedex) were searched from 1980 to 2019. To analyze the data, a random-effects model was used to combine the differences in the mean of studies in STATA Software (version 12).
RESULTS
A total of 724 articles were found with initial searching that 474 duplicate articles, 228 articles were excluded by reviewing the title and abstracts, and 17 articles were excluded from the study due to lack of inclusion criteria. Finally, five articles entered the meta-analysis phase. The mean difference value for zinc concentration of blood serum was 2.01 (95% confidence interval (CI): 0.36-3.66) and for copper was 1.04 (95% CI: 0.01-2.07). In both populations, the heterogeneity was found between studies ( = 97.4, < 0.001).
CONCLUSION
Probably higher serum levels of copper and zinc could be one way to help to do a primary screening of OSCC in suspected patients.
背景
口腔鳞状细胞癌（OSCC）是全球第六大常见癌症，占口腔恶性肿瘤的90%。本研究旨在调查OSCC患者血清中某些代谢元素的变化。
材料与方法
本研究检索了1980年至2019年的国际数据库，如PubMed、Science Direct、Scopus、Web of Science和国家数据库（Magiran、IranMedex）。为分析数据，使用随机效应模型在STATA软件（版本12）中合并研究均值的差异。
结果
初步检索共找到724篇文章，其中474篇为重复文章，通过标题和摘要审查排除228篇文章，因缺乏纳入标准又排除17篇文章。最后，5篇文章进入荟萃分析阶段。血清锌浓度的平均差值为2.01（95%置信区间（CI）：0.36 - 3.66），铜的平均差值为1.04（95%CI：0.01 - 2.07）。在这两个人群中，研究之间均存在异质性（I² = 97.4，P < 0.001）。
结论
血清铜和锌水平可能较高可能是对疑似OSCC患者进行初步筛查的一种方法。
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