Hansen Erik Sören Halvard, Rasmusen Hanne Kruuse, Hostrup Morten, Hellsten Ylva, Backer Vibeke
Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Department of Respiratory Medicine, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark.
Eur Clin Respir J. 2023 Sep 4;10(1):2251256. doi: 10.1080/20018525.2023.2251256. eCollection 2023.
To evaluate if high-intensity interval training three times weekly for 12 weeks improves asthma control in overweight, postmenopausal women with uncontrolled, late-onset asthma.
The reported study is a randomized clinical pilot study (www.clinicaltrials.gov; NCT03747211) that compared 12 weeks of high-intensity interval training (spinning) with usual care. The five-question Asthma Control Questionnaire (ACQ-5) was used as primary outcome. Secondary measures included systemic inflammation and inflammation of the airways, body composition, and cardiac function during exercise.
We included 12 women with asthma (mean age 65 years (SD 6); mean body mass index 30 kg/m (SD 2)) from whom eight were randomized to exercise and four to control. Baseline ACQ-5 was 1.95 (SD 0.53) in the control group and 2.03 (0.54) in the exercise group. Patients had a mean blood eosinophil level of 0.16 × 10cells/L (SD 0.07) and a mean fraction of exhaled nitric oxide of 23 ppb (SD 25). Mixed models showed that participants in the exercise group reduced their ACQ-5 by 0.55 points (95%CI -1.10 to -0.00; = 0.08) compared with the control group. The exercise group significantly reduced their mean body fat percentage (-2.7%; 95%CI -4.5 to -0.8; = 0.02), fat mass (-2.8 kg; 95%CI -5.1 to -0.4; = 0.044) and android fat mass (-0.33 kg; 95%CI -0.60- -0.06; = 0.038). In analyses of cardiac measures, we saw no significant effects on right ventricular function (fractional area change), diastolic function or left ventricular function.
Although changes in ACQ-5 were slightly insignificant, these preliminary findings indicate that aerobic exercise training can be used as a means to improve asthma control in overweight, postmenopausal women with asthma.
评估每周进行三次高强度间歇训练，持续12周，是否能改善超重、绝经后且哮喘控制不佳的迟发性哮喘女性的哮喘控制情况。
本报告的研究是一项随机临床试验性研究（www.clinicaltrials.gov；NCT03747211），比较了12周的高强度间歇训练（动感单车）与常规护理。使用五题哮喘控制问卷（ACQ-5）作为主要结局指标。次要测量指标包括全身炎症和气道炎症、身体成分以及运动期间的心脏功能。
我们纳入了12名哮喘女性（平均年龄65岁（标准差6）；平均体重指数30kg/m²（标准差2）），其中8人被随机分配至运动组，4人被分配至对照组。对照组的基线ACQ-5为1.95（标准差0.53），运动组为2.03（0.54）。患者的平均血嗜酸性粒细胞水平为0.16×10⁹/L（标准差0.07），平均呼出一氧化氮分数为23ppb（标准差25）。混合模型显示，与对照组相比，运动组参与者的ACQ-5降低了0.55分（95%置信区间-1.10至-0.00；P=0.08）。运动组显著降低了其平均体脂百分比（-2.7%；95%置信区间-4.5至-0.8；P=0.02）、脂肪量（-2.8kg；95%置信区间-5.1至-0.4；P=0.044）和腹部脂肪量（-0.33kg；95%置信区间-0.60至-0.06；P=0.038）。在心脏测量分析中，我们未观察到对右心室功能（面积变化分数）、舒张功能或左心室功能有显著影响。
尽管ACQ-5的变化略显不显著，但这些初步研究结果表明，有氧运动训练可作为改善超重、绝经后哮喘女性哮喘控制情况的一种方法。
