Chávez-Iñiguez Jonathan Samuel, Villegas-Gutiérrez Luz Yareli, Gallardo-González Alejandro Martínez
Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.
University Center for Health Sciences, University of Guadalajara, Guadalajara, Mexico.
Front Nephrol. 2022 Jul 7;2:916151. doi: 10.3389/fneph.2022.916151. eCollection 2022.
Within the multiple communication pathways of the intestine-kidney axis, one of the most important pathways is the interaction between the commensals of the intestinal microbiome, through the production of short-chain fatty acids, and the segments of the nephron. These interactions maintain a perfect environmental balance. During AKI, there are negative repercussions in all organs, and the systemic interconnection is related in part to the intense inflammation and the uremic environment that this syndrome generates. For example, in the intestine, the microbiome is severely affected, with a decrease in benign bacteria that promote anti-inflammatory effects and an increase in negative, pro-inflammatory bacteria. This scenario of intestinal dysbiosis widens the inflammatory loop that favors worsening kidney function and the probability of dying. It is possible that the manipulation of the intestinal microbiome with probiotics, prebiotics and symbiotics is a reasonable therapeutic goal for AKI.
在肠-肾轴的多种通讯途径中，最重要的途径之一是肠道微生物群的共生菌通过产生短链脂肪酸与肾单位各节段之间的相互作用。这些相互作用维持着完美的环境平衡。在急性肾损伤期间，所有器官都会受到负面影响，全身的相互联系部分与该综合征引发的强烈炎症和尿毒症环境有关。例如，在肠道中，微生物群受到严重影响，促进抗炎作用的良性细菌减少，而具有负面促炎作用的细菌增加。这种肠道生态失调的情况会扩大炎症循环，进而导致肾功能恶化和死亡几率增加。用益生菌、益生元和合生元对肠道微生物群进行调控可能是急性肾损伤一个合理的治疗目标。
