Waeber B, Schaller M D, Nussberger J, Bussien J P, Hofbauer K G, Brunner H R
Am J Physiol. 1984 Dec;247(6 Pt 2):H895-901. doi: 10.1152/ajpheart.1984.247.6.H895.
The effect of vasopressin released by cigarette smoking on blood pressure (BP), heart rate (HR), and skin blood flow (SBF) was investigated in 12 normotensive habitual smokers. At a 1-wk interval, each subject smoked within 10 min two cigarettes before and after intravenous injection of either the specific vascular vasopressin antagonist d(CH2)5Tyr(Me)AVP (5 micrograms/kg) or its vehicle administered in double-blind fashion. SBF was assessed with a laser Doppler flowmeter. Smoking increased plasma vasopressin (P less than 0.01). In six subjects subsequently treated with the antagonist, plasma vasopressin rose to greater than 10 pg/ml and SBF fell by 18.2 +/- 4.8%. This SBF reduction was prevented by the vasopressin antagonist. In contrast, the vehicle had no effect. In the 24 studies taken together, there was a significant correlation (r = -0.60, P less than 0.01) between the SBF decrease during the first smoking period and the plasma vasopressin levels measured afterwards. The BP and HR rise caused by smoking was not modified by the antagonist. Thus it appears that the decrease in SBF induced by smoking is due to enhanced vasopressin secretion.
在12名血压正常的习惯性吸烟者中，研究了吸烟释放的血管加压素对血压（BP）、心率（HR）和皮肤血流量（SBF）的影响。在1周的间隔时间内，每位受试者在静脉注射特异性血管加压素拮抗剂d(CH2)5Tyr(Me)AVP（5微克/千克）或其溶媒前后10分钟内各吸两支烟，采用双盲方式给药。用激光多普勒血流仪评估皮肤血流量。吸烟使血浆血管加压素升高（P<0.01）。在随后接受拮抗剂治疗的6名受试者中，血浆血管加压素升至大于10皮克/毫升，皮肤血流量下降了18.2±4.8%。这种皮肤血流量的减少被血管加压素拮抗剂阻止。相比之下，溶媒没有效果。在总共24项研究中，第一个吸烟期皮肤血流量的减少与随后测量的血浆血管加压素水平之间存在显著相关性（r = -0.60，P<0.01）。吸烟引起的血压和心率升高未被拮抗剂改变。因此，吸烟引起的皮肤血流量减少似乎是由于血管加压素分泌增加所致。
