Bussien J P, Waeber B, Nussberger J, Schaller M D, Gavras H, Hofbauer K, Brunner H R
Am J Physiol. 1984 Jan;246(1 Pt 2):H143-7. doi: 10.1152/ajpheart.1984.246.1.H143.
The inhibitor of the pressor effect of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, at a dose of 5 micrograms/kg iv was shown in four healthy volunteers to antagonize the blood pressure, heart rate, and skin blood flow response to a lysine vasopressin infusion of 1 mIU X kg-1 X min-1. The inhibition lasted for more than 2 h. When the same dose of the vasopressin antagonist was administered to 10 healthy normally hydrated volunteers with their renin system intact or acutely blocked by 25 mg of captopril po, none of the above parameters changed. It is concluded that circulating vasopressin, even in the face of a blocked renin-angiotensin system, does not actively contribute to maintenance of cardiovascular homeostasis.
精氨酸加压素（AVP）升压作用的抑制剂d(CH2)5Tyr(Me)AVP，以5微克/千克静脉注射的剂量，在4名健康志愿者身上显示出能拮抗对1毫国际单位×千克-1×分钟-1的赖氨酸加压素输注所产生的血压、心率和皮肤血流反应。这种抑制持续超过2小时。当将相同剂量的加压素拮抗剂给予10名肾素系统完整或被口服25毫克卡托普利急性阻断的健康正常水合志愿者时，上述参数均未改变。得出的结论是，即使在肾素-血管紧张素系统被阻断的情况下，循环中的加压素也不会积极参与维持心血管稳态。
