Sirota R A, Kimmel P L, Trichtinger M D, Diamond B F, Stein H D, Yudis M
Arch Intern Med. 1986 Oct;146(10):2070-1.
Metoclopramide hydrochloride is an antiemetic and gastric motility stimulant with a wide variety of extrapyramidal side effects, including parkinsonism. We describe two patients with end-stage renal disease secondary to diabetes mellitus treated with hemodialysis who developed extrapyramidal symptoms during treatment with metoclopramide. One patient with preexisting, well-controlled Parkinson's disease developed increasing rigidity and bradykinesia that became completely refractory to treatment with L-dopa and bromocriptine while taking metoclopramide for diabetic gastroparesis. A second patient with no history of Parkinson's disease developed a resting tremor and facial dyskinesia during treatment with metoclopramide. In both cases, discontinuation of metoclopramide therapy led to prompt improvement of symptoms.
盐酸甲氧氯普胺是一种止吐药和胃动力兴奋剂，具有多种锥体外系副作用，包括帕金森综合征。我们描述了两名因糖尿病继发终末期肾病而接受血液透析治疗的患者，他们在使用甲氧氯普胺治疗期间出现了锥体外系症状。一名患有帕金森病且病情此前得到良好控制的患者，在因糖尿病胃轻瘫服用甲氧氯普胺期间，出现了日益加重的僵硬和运动迟缓，对左旋多巴和溴隐亭治疗完全无效。第二名无帕金森病病史的患者在使用甲氧氯普胺治疗期间出现了静止性震颤和面部运动障碍。在这两例病例中，停用甲氧氯普胺治疗后症状迅速改善。
