Grimes J D, Hassan M N, Preston D N
Can Med Assoc J. 1982 Jan 1;126(1):23-5.
Metoclopramide hydrochloride is now commonly prescribed for a variety of gastrointestinal disorders. Over a 2-year period 18 patients with neurologic disorders induced by metoclopramide were assessed at the Parkinson's disease clinic of the Ottawa Civic Hospital. During metoclopramide therapy acute transient dystonic reactions were seen in 4 patients, and parkinsonism, which was frequently misdiagnosed and treated as classic Parkinson's disease, was seen in 12 patients. After treatment with metoclopramide was stopped, tardive dyskinesia appeared in seven patients and has persisted for up to 15 months in three patients. Parkinsonism and tardive dyskinesia occurred in older patients undergoing long-term therapy with metoclopramide. This experience, therefore, suggests that such treatment, especially in older patients, should be avoided.
盐酸甲氧氯普胺目前常用于治疗各种胃肠道疾病。在两年时间里，渥太华市民医院帕金森病诊所对18例由甲氧氯普胺引起的神经系统疾病患者进行了评估。在甲氧氯普胺治疗期间，4例患者出现急性短暂性肌张力障碍反应，12例患者出现帕金森综合征，该综合征常被误诊为经典帕金森病并进行治疗。停用甲氧氯普胺治疗后，7例患者出现迟发性运动障碍，3例患者的迟发性运动障碍持续长达15个月。帕金森综合征和迟发性运动障碍发生在接受甲氧氯普胺长期治疗的老年患者中。因此，这一经验表明，应避免进行此类治疗，尤其是在老年患者中。
