Allon M, Hall W D, Macon E J
Arch Intern Med. 1986 Oct;146(10):2075-6.
Severe prolonged hypotension developed in a hypertensive patient several hours after the initial doses of minoxidil therapy. Hemodynamic measurements revealed a markedly low systemic vascular resistance and a markedly high cardiac output. Other causes of hypotension were ruled out. The patient's hemodynamic abnormalities lasted three days after minoxidil therapy was discontinued, and she then reverted to hypertension. Thus, a 10-mg starting dose of minoxidil may produce profound life-threatening hypotension, which can last up to 72 hours.
一名高血压患者在初始剂量米诺地尔治疗数小时后出现严重的持续性低血压。血流动力学测量显示全身血管阻力显著降低，心输出量显著升高。排除了其他导致低血压的原因。在停用米诺地尔治疗后，患者的血流动力学异常持续了三天，之后又恢复为高血压。因此，米诺地尔10毫克的起始剂量可能会导致严重的危及生命的低血压，这种低血压可持续长达72小时。
