用于嗅觉丧失的视觉模拟量表作为鼻息肉慢性鼻窦炎快速检测方法的验证

Validation of a Visual Analog Scale for Loss of Smell as a Quick Test in Chronic Rhinosinusitis With Nasal Polyps.

作者信息

Alobid I, Calvo-Henríquez C, Viveros-Díez P, López-Chacón M, Rojas-Lechuga M J, Langdon C, Marin C, Mullol J

机构信息

Skull Base Unit, ENT Department, Hospital Clínic Barcelona, IDIBAPS, Barcelona University, Barcelona, Catalonia, Spain.

INGENIO, IRCE, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

出版信息

J Investig Allergol Clin Immunol. 2024 Dec 5;34(6):377-384. doi: 10.18176/jiaci.0937. Epub 2023 Sep 6.

DOI:10.18176/jiaci.0937

PMID:37675801

Abstract

BACKGROUND AND OBJECTIVES

The diagnostic criteria of chronic rhinosinusitis with nasal polyps (CRSwNP) include olfactory dysfunction. We hypothesize that patients with CRSwNP can self-assess their sense of smell better using a visual analog scale (VAS) than using smell tests.

METHODS

A controlled cross-sectional study was performed. Adults diagnosed with severe CRSwNP waiting for endoscopic sinus surgery were included. A cohort of healthy controls was also studied. All participants completed the Barcelona Smell Test 24 (BAST-24), the 22-item Sinonasal Outcomes Test 22 (SNOT-22), and a VAS for loss of smell. Patients with CRSwNP underwent blood testing (eosinophil count, total serum IgE), computed tomography (Lund-Mackay Score), and nasal endoscopy.

RESULTS

The study population comprised 138 patients with severe CRSwNP and 40 controls. The BAST-24 identification score was strongly correlated with the VAS score in the CRSwNP group (p=-0.79, P<.001) but not in the control group (p=-0.14; P=.39), this difference between groups being statistically significant (P<.001). A significant correlation was found between SNOT-22 item 21 (loss of smell) and BAST-24 identification (p=-0.65, P<.001), this difference being statistically significant (Z=-2.43; P=.015). The area under the receiver operating curve was 0.85, with 72.5% sensitivity and 93.1% specificity.

CONCLUSION

This study demonstrates a potential role of the VAS score for the screening of olfactory dysfunction in severe CRSwNP in daily clinical practice.

摘要

背景与目的

伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP）的诊断标准包括嗅觉功能障碍。我们假设，与嗅觉测试相比，CRSwNP患者使用视觉模拟量表（VAS）能更好地自我评估嗅觉。

方法

进行了一项对照横断面研究。纳入等待内镜鼻窦手术的成年重度CRSwNP患者。还研究了一组健康对照者。所有参与者均完成了巴塞罗那嗅觉测试24项（BAST - 24）、22项鼻鼻窦结局测试22项（SNOT - 22）以及嗅觉丧失的VAS。CRSwNP患者接受了血液检测（嗜酸性粒细胞计数、总血清IgE）、计算机断层扫描（Lund - Mackay评分）和鼻内镜检查。

结果

研究人群包括138例重度CRSwNP患者和40例对照者。CRSwNP组中，BAST - 24识别分数与VAS分数显著相关（p = - 0.79，P <.001），而对照组中无显著相关性（p = - 0.14；P =.39），两组间差异具有统计学意义（P <.001）。发现SNOT - 22第21项（嗅觉丧失）与BAST - 24识别之间存在显著相关性（p = - 0.65，P <.001），该差异具有统计学意义（Z = - 2.43；P =.015）。受试者工作特征曲线下面积为0.85，敏感性为72.5%，特异性为93.1%。