Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
J Allergy Clin Immunol Pract. 2024 Nov;12(11):2898-2905. doi: 10.1016/j.jaip.2024.07.019. Epub 2024 Jul 30.
Chronic rhinosinusitis (CRS) is characterized by chronic inflammation of the sinonasal mucosa, affects over 12% of the US population, and costs over $20 billion annually. CRS can be divided into 2 major phenotypes based on whether nasal polyps are present (chronic rhinosinusitis with nasal polyps [CRSwNP]) or absent (chronic rhinosinusitis without nasal polyps). This grand rounds review will discuss the clinical approach to patients with CRSwNP, including typical presentations, workup, and currently available treatment options. Tools that physicians can use to assess subjective sinonasal symptoms, as well as objective measures of disease, will be reviewed. Additional focus will be on recognizing clinical comorbidities commonly associated with CRSwNP, including asthma, bronchiectasis, allergic rhinitis, and nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. Clinical outcomes can be improved by providing a comprehensive approach to evaluating (and managing) patients with CRSwNP.
慢性鼻-鼻窦炎（CRS）的特征为鼻-鼻窦黏膜的慢性炎症，影响超过美国总人口的 12%，每年耗费超过 200 亿美元。CRS 可根据是否存在鼻息肉（伴有鼻息肉的慢性鼻-鼻窦炎 [CRSwNP]）分为 2 种主要表型，或不存在鼻息肉（不伴有鼻息肉的慢性鼻-鼻窦炎）。本次大查房将讨论 CRSwNP 患者的临床处理方法，包括典型表现、检查和目前可用的治疗选择。将回顾医生用于评估主观鼻-鼻窦症状以及疾病客观指标的工具。此外，还将重点关注识别与 CRSwNP 常见相关的临床合并症，包括哮喘、支气管扩张、变应性鼻炎和非甾体抗炎药加重的呼吸系统疾病。通过提供全面的方法评估（和管理）CRSwNP 患者，可以改善临床结局。
