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影响范围:如果毒力在能量上是昂贵的,它怎么能被维持呢?

mSphere of Influence: If virulence is energetically costly, how can it be maintained?

机构信息

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland, USA.

出版信息

mSphere. 2023 Oct 24;8(5):e0031223. doi: 10.1128/msphere.00312-23. Epub 2023 Sep 7.

DOI:10.1128/msphere.00312-23
PMID:37676232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10597342/
Abstract

Kimberly Davis works in the field of bacterial pathogenesis and studies heterogeneity in bacterial populations within host tissues. In this mSphere of Influence article, she reflects on how the paper "Stabilization of cooperative virulence by the expression of an avirulent phenotype" by M. Diard et al. (M. Diard et al., 494:353-6, 2013, DOI: 10.1038/nature11913) impacted the way she thinks about bacterial population dynamics and the costs and benefits of producing virulence factors during infection.

摘要

金伯利·戴维斯(Kimberly Davis)从事细菌发病机制领域的研究,专注于宿主组织内细菌群体的异质性。在本期《mSphere 影响力》文章中,她回顾了 M. Diard 等人的论文“通过表达无毒表型稳定共生毒力”(M. Diard 等,494:353-6,2013,DOI: 10.1038/nature11913)对她思考细菌种群动态以及在感染过程中产生毒力因子的成本和收益的方式产生的影响。

相似文献

1
mSphere of Influence: If virulence is energetically costly, how can it be maintained?影响范围:如果毒力在能量上是昂贵的,它怎么能被维持呢?
mSphere. 2023 Oct 24;8(5):e0031223. doi: 10.1128/msphere.00312-23. Epub 2023 Sep 7.
2
mSphere of Influence: How I Learned to Love Bacteria and their Tangled Evolutionary Tree.《影响范围:我是如何爱上细菌及其错综复杂的进化树的》。
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mSphere of Influence: Coordinating effective clearance of bacterial bloodstream infections.影响范围:协调有效清除细菌性血流感染。
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of Influence: There's More to (a Pathogen's) Life than Growing Fast.影响力:(病原体)的生活不仅仅是快速生长。
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本文引用的文献

1
NO-Stressed Has Decreased Cell Division Rates in the Mouse Spleen.无应激减少了小鼠脾脏中的细胞分裂率。
Infect Immun. 2022 Aug 18;90(8):e0016722. doi: 10.1128/iai.00167-22. Epub 2022 Jul 11.
2
Yersinia pseudotuberculosis doxycycline tolerance strategies include modulating expression of genes involved in cell permeability and tRNA modifications.假结核耶尔森氏菌的强力霉素耐受策略包括调节与细胞通透性和 tRNA 修饰相关基因的表达。
PLoS Pathog. 2022 May 16;18(5):e1010556. doi: 10.1371/journal.ppat.1010556. eCollection 2022 May.
3
Modifying TIMER to generate a slow-folding DsRed derivative for optimal use in quickly-dividing bacteria.修改 TIMER 以产生缓慢折叠的 DsRed 衍生物,以便在快速分裂的细菌中最佳使用。
PLoS Pathog. 2021 Jul 2;17(7):e1009284. doi: 10.1371/journal.ppat.1009284. eCollection 2021 Jul.
4
Subpopulations of Stressed Yersinia pseudotuberculosis Preferentially Survive Doxycycline Treatment within Host Tissues.应激型假结核耶尔森菌亚群在宿主组织内优先耐受强力霉素治疗。
mBio. 2020 Aug 4;11(4):e00901-20. doi: 10.1128/mBio.00901-20.
5
One for All, but Not All for One: Social Behavior during Bacterial Diseases.一荣俱荣,一损俱损:细菌疾病期间的社会行为。
Trends Microbiol. 2019 Jan;27(1):64-74. doi: 10.1016/j.tim.2018.09.001. Epub 2018 Sep 19.
6
All Are Not Created Equal: Phenotypic Adaptation to Distinct Niches Within Mammalian Tissues.并非生来平等:哺乳动物组织内对不同生态位的表型适应
Front Cell Infect Microbiol. 2018 Aug 3;8:261. doi: 10.3389/fcimb.2018.00261. eCollection 2018.
7
Community behavior and spatial regulation within a bacterial microcolony in deep tissue sites serves to protect against host attack.深部组织部位细菌微菌落内的群体行为和空间调控有助于抵御宿主攻击。
Cell Host Microbe. 2015 Jan 14;17(1):21-31. doi: 10.1016/j.chom.2014.11.008. Epub 2014 Dec 11.
8
Bistable expression of virulence genes in salmonella leads to the formation of an antibiotic-tolerant subpopulation.沙门氏菌中毒力基因的双稳态表达导致形成抗生素耐受亚群。
PLoS Biol. 2014 Aug 19;12(8):e1001928. doi: 10.1371/journal.pbio.1001928. eCollection 2014 Aug.
9
Antibiotic treatment selects for cooperative virulence of Salmonella typhimurium.抗生素治疗会选择鼠伤寒沙门氏菌的协同毒力。
Curr Biol. 2014 Sep 8;24(17):2000-5. doi: 10.1016/j.cub.2014.07.028. Epub 2014 Aug 14.
10
Stabilization of cooperative virulence by the expression of an avirulent phenotype.通过表达无毒表型稳定合作毒力。
Nature. 2013 Feb 21;494(7437):353-6. doi: 10.1038/nature11913.