通过自噬相关蛋白8（ATG8）从热损伤中拯救高尔基体：是修复而非清理。
Rescuing the Golgi from heat damages by ATG8: restoration rather than clean-up.
作者信息
Luo Anni, Liu Jian-Xiang
机构信息
State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, 310027, China.
出版信息
Stress Biol. 2023 Jun 26;3(1):19. doi: 10.1007/s44154-023-00100-6.
High temperature stress poses significant adverse effects on crop yield and quality. Yet the molecular mechanisms underlying heat stress tolerance in plants/crops, especially regarding the organellar remodeling and homeostasis, are largely unknown. In a recent study, Zhou et al. reported that autophagy-related 8 (ATG8), a famous regulator involved in autophagy, plays a new role in Golgi restoration upon heat stress. Golgi apparatus is vacuolated following short-term acute heat stress, and ATG8 is translocated to the dilated Golgi membrane and interacts with CLATHRIN LIGHT CHAIN 2 (CLC2) to facilitate Golgi restoration, which is dependent on the ATG conjugation system, but not of the upstream autophagic initiators. These exciting findings broaden the fundamental role of ATG8, and elucidate the organelle-level restoration mechanism of Golgi upon heat stress in plants.
高温胁迫对作物产量和品质产生重大不利影响。然而，植物/作物耐热性的分子机制，尤其是关于细胞器重塑和稳态的机制，在很大程度上尚不清楚。在最近的一项研究中，周等人报道，参与自噬的著名调节因子自噬相关蛋白8（ATG8）在热胁迫后高尔基体恢复中发挥新作用。短期急性热胁迫后，高尔基体出现液泡化，ATG8转移到扩张的高尔基体膜上，并与网格蛋白轻链2（CLC2）相互作用以促进高尔基体恢复，这依赖于ATG缀合系统，但不依赖于上游自噬启动子。这些令人兴奋的发现拓宽了ATG8的基本作用，并阐明了植物热胁迫后高尔基体的细胞器水平恢复机制。
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