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Blastoids generated purely from embryonic stem cells both in mice and humans.

作者信息

Wu Baojiang, Wang Yanqiu, Yan Jia, Liu Mengya, Li Xihe, Tang Fuchou, Bao Siqin

机构信息

The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010020, China.

Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot, 010020, China.

出版信息

Sci China Life Sci. 2024 Feb;67(2):418-420. doi: 10.1007/s11427-023-2419-9. Epub 2023 Sep 4.

DOI:10.1007/s11427-023-2419-9
PMID:37676403
Abstract
摘要

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本文引用的文献

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Highly efficient generation of blastocyst-like structures from spliceosomes-repressed mouse totipotent blastomere-like cells.高效生成内胚层样结构从剪接体抑制的全能性胚胎细胞样细胞。
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2
A chemically defined system supports two distinct types of stem cell from a single blastocyst and their self-assembly to generate blastoid.化学定义系统支持从单个囊胚中分离出两种不同类型的干细胞,并通过它们的自我组装生成类囊胚。
Cell Prolif. 2023 Jun;56(6):e13396. doi: 10.1111/cpr.13396. Epub 2023 Jan 2.
3
Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.
Sci China Life Sci. 2025 Feb 17. doi: 10.1007/s11427-024-2741-1.
4
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells.瞬时化学介导的表观遗传调控赋予人类始发态多能干细胞不受限制的谱系分化潜能。
Sci China Life Sci. 2025 Apr;68(4):1084-1101. doi: 10.1007/s11427-024-2660-3. Epub 2025 Jan 13.
5
Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches.通过转录组学和蛋白质组学方法揭示的模式原生生物扇形游仆虫在不同生命周期阶段表达的基因和蛋白质。
Sci China Life Sci. 2025 Jan;68(1):232-248. doi: 10.1007/s11427-023-2605-9. Epub 2024 Sep 10.
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Single-cell omics: experimental workflow, data analyses and applications.单细胞组学:实验工作流程、数据分析及应用
Sci China Life Sci. 2025 Jan;68(1):5-102. doi: 10.1007/s11427-023-2561-0. Epub 2024 Jul 23.
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Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit.通过 CRISPR/Cas9 敲除方法的重新评估表明,多个多能性相关 lncRNAs 对于维持多能性是可有可无的,而 Snora73a/b 对于多能性的退出是必不可少的。
Sci China Life Sci. 2024 Oct;67(10):2198-2212. doi: 10.1007/s11427-023-2594-3. Epub 2024 Jul 9.
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Sci China Life Sci. 2024 Aug;67(8):1676-1696. doi: 10.1007/s11427-023-2557-x. Epub 2024 May 11.
在胚胎干细胞中抑制从头 DNA 甲基化可允许一条非合法的命运轨迹。
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