Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge parkIII, Greater Noida, 201310, U.P., India.
Amity Institute of Biotechnology, Amity University, Ranchi, 834002, Jharkhand, India.
Mol Biol Rep. 2023 Nov;50(11):9453-9468. doi: 10.1007/s11033-023-08751-4. Epub 2023 Sep 7.
Osteoporosis is a metabolic bone disorder that over time results in bone loss and raises the risk of fracture. The condition is frequently silent and only becomes apparent when fractures develop. Osteoporosis is treated with pharmacotherapy as well as non-pharmacological therapies such as mineral supplements, lifestyle changes, and exercise routines. Herbal medicine is frequently used in clinical procedures because of its low risk of adverse effects and cost-effective therapeutic results. In the current review, we have used a thorough strategy to identify some known medicinal plants with anti-osteoporosis capabilities, their origin, active ingredients, and pharmacological information. Furthermore, several signaling pathways, such as the apoptotic pathway, transcription factors, the Wnt/-catenin signaling pathway, and others, are regulated by bioactive components and help to improve bone homeostasis. This review will provide a better understanding of the anti-osteoporotic effects of bioactive components and the concomitant modulations of signaling pathways.
骨质疏松症是一种代谢性骨病，随着时间的推移会导致骨质流失，增加骨折的风险。这种疾病通常没有明显症状，只有在发生骨折时才会显现出来。骨质疏松症的治疗方法包括药物治疗以及非药物治疗，如矿物质补充剂、生活方式改变和运动常规。由于草药的不良反应风险低且治疗效果具有成本效益，因此经常在临床程序中使用。在本次综述中，我们采用了一种全面的策略来确定一些具有抗骨质疏松能力的已知药用植物，包括它们的来源、活性成分和药理学信息。此外，几种信号通路，如凋亡通路、转录因子、Wnt/-连环蛋白信号通路等，都受到生物活性成分的调节，有助于改善骨稳态。本综述将更好地了解生物活性成分的抗骨质疏松作用以及信号通路的伴随调节。
