Indiana University.
Indiana University-Purdue University Indianapolis.
Oncol Nurs Forum. 2023 Jun 15;50(4):475-485. doi: 10.1188/23.ONF.475-485.
To examine symptoms and symptom clusters in patients with colorectal cancer (CRC) with or without diabetes at three key periods (0-6 months, 12-18 months, and 24-30 months) post-initial chemotherapy.
SAMPLE & SETTING: Patients with CRC from a cancer center in the midwestern United States between January 2007 and December 2017.
METHODS & VARIABLES: Eight of the most common symptoms (fatigue, gastrointestinal issues, depression, anxiety, peripheral neuropathy, physical function, cognition, and sleep disturbance) reported by patients with CRC and patients with diabetes were extracted from electronic health records. Exploratory factor analysis was used to identify symptom clusters, which were assessed for patterns and clinical relevance.
Gastrointestinal issues and fatigue were the most prevalent symptoms in patients with CRC at each period. Across the three periods, patients with CRC and diabetes had more symptom clusters (n = 7) compared to patients with CRC without diabetes (n = 4). No stable symptom clusters were identified for either group.
Oncology clinicians must recognize that patients with CRC and diabetes may present with exacerbated symptoms or symptom clusters. Ongoing assessment and monitoring of patients with CRC and diabetes for symptoms and symptom clusters is important because they may be at an increased risk for higher symptom burden.
在初始化疗后三个关键时期（0-6 个月、12-18 个月和 24-30 个月），研究伴有或不伴有糖尿病的结直肠癌（CRC）患者的症状和症状群。
来自美国中西部一家癌症中心的 CRC 患者，时间为 2007 年 1 月至 2017 年 12 月。
从电子病历中提取了 8 种最常见的 CRC 患者和糖尿病患者报告的症状（疲劳、胃肠道问题、抑郁、焦虑、周围神经病变、身体功能、认知和睡眠障碍）。采用探索性因子分析来确定症状群，并评估其模式和临床相关性。
胃肠道问题和疲劳是 CRC 患者在每个时期最常见的症状。在三个时期，患有 CRC 和糖尿病的患者比患有 CRC 但无糖尿病的患者有更多的症状群（n=7）。两组均未确定稳定的症状群。
肿瘤临床医生必须认识到，患有 CRC 和糖尿病的患者可能表现出症状加重或症状群。对患有 CRC 和糖尿病的患者进行症状和症状群的持续评估和监测很重要，因为他们可能面临更高的症状负担风险。
