Hosseini Motaharesadat, Shafiee Abbas
School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, QLD, Australia; ARC Industrial Transformation Training Centre for Multiscale 3D Imaging, Modelling and Manufacturing (M3D), Queensland University of Technology, Brisbane, QLD, Australia.
Herston Biofabrication Institute, Metro North Hospital and Health Service, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Brisbane, QLD, Australia; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Prog Mol Biol Transl Sci. 2023;199:327-350. doi: 10.1016/bs.pmbts.2023.03.002. Epub 2023 Apr 1.
Differentiated skin cells have limited self-renewal capacity; thus, the application of stem/progenitor cells, adult or induced stem cells, has attracted much attention for wound healing applications. Upon skin injury, vascularization, known as a highly dynamic process, occurs with the contribution of cells, the extracellular matrix, and relevant growth factors. Considering the importance of this process in tissue regeneration, several strategies have been proposed to enhance angiogenesis and accelerate wound healing. Previous studies report the effectiveness of stem/progenitor cells in skin wound healing by facilitating the vascularization process. This chapter reviews and highlights some of the key and recent investigations on application of stem/progenitor cells to induce skin revascularization after trauma.
分化的皮肤细胞自我更新能力有限；因此，干细胞/祖细胞、成体干细胞或诱导干细胞的应用在伤口愈合应用中备受关注。皮肤受伤后，血管生成是一个高度动态的过程，细胞、细胞外基质和相关生长因子都参与其中。考虑到这一过程在组织再生中的重要性，人们提出了几种策略来促进血管生成并加速伤口愈合。先前的研究报告了干细胞/祖细胞通过促进血管生成过程在皮肤伤口愈合中的有效性。本章回顾并重点介绍了一些关于应用干细胞/祖细胞诱导创伤后皮肤血管再生的关键和最新研究。
