CTLA4 + 49A/G 多态性与肝细胞癌风险的关联：系统评价和荟萃分析。
Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis.
机构信息
Department of Intervention Chemotherapy, Zibo First Hospital, Zibo, China.
Oncology, Zibo First Hospital, Zibo, China.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2024;43(4):302-315. doi: 10.1080/15257770.2023.2255626. Epub 2023 Sep 7.
The aim of this systematic review and meta-analysis was to compile the data examining the association between the + 49 A/G polymorphism and the risk for HCC. Multiple databases were systematically searched for eligible studies and the pooled odds ratios (ORs) were generated using five genetic models. Pooled data from 11 studies with 3,055 HCC patients and 3,450 controls found no statistically significant association between the polymorphism and HCC risk, both overall and in subgroup analyses. In conclusion, the current meta-analysis shows that the + 49 A/G polymorphism is not significantly associated with the risk of developing HCC.
本系统评价和荟萃分析的目的是汇总数据，以检验 + 49 A/G 多态性与 HCC 风险之间的关联。通过系统检索多个数据库，采用五种遗传模型生成汇总优势比（OR）。综合 11 项研究的数据，共纳入 3055 例 HCC 患者和 3450 例对照，无论整体还是亚组分析，均未发现该多态性与 HCC 风险之间存在统计学显著关联。综上所述，本荟萃分析表明， + 49 A/G 多态性与 HCC 的发病风险无显著相关性。
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