Department of Epidemic Disease Research, Institutes for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1881, Dammam 31441, Saudi Arabia.
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404, Taiwan.
Pharmacol Res. 2021 Feb;164:105364. doi: 10.1016/j.phrs.2020.105364. Epub 2020 Dec 4.
In the past decades, the branch of complementary and alternative medicine based therapeutics has gained considerable attention worldwide. Pharmacological efficacy of various traditional medicinal plants, their products and/or product derivatives have been explored on an increasing scale. Tanshinone IIA (Tan IIA) is a pharmacologically active lipophilic component of Salvia miltiorrhiza extract. Tan IIA shares a history of high repute in Traditional Chinese Medicine. Reckoning with these, the present review collates the pharmacological properties of Tan IIA with a special emphasis on its therapeutic potential against diverse diseases including cardiovascular diseases, cerebrovascular diseases, cancer, diabetes, obesity and neurogenerative diseases. Further, possible applications of various therapeutic preparations of Tan IIA were discussed with special emphasis on nano-based drug delivery formulations. Considering the tremendous advancement in the field of nanomedicine and the therapeutic potential of Tan IIA, the convergence of these two aspects can be foreseen with great promise in clinical application.
在过去的几十年中，基于补充和替代医学的治疗方法在全球范围内受到了相当大的关注。各种传统药用植物、其产品和/或产品衍生物的药理学功效已在不断扩大的范围内得到探索。丹参酮 IIA（Tan IIA）是丹参提取物中一种具有药理活性的亲脂性成分。Tan IIA 在中医药中有着悠久的良好声誉。有鉴于此，本综述总结了 Tan IIA 的药理学特性，特别强调了其在治疗心血管疾病、脑血管疾病、癌症、糖尿病、肥胖症和神经退行性疾病等多种疾病方面的治疗潜力。此外，还讨论了 Tan IIA 的各种治疗制剂的可能应用，特别强调了基于纳米的药物传递制剂。考虑到纳米医学领域的巨大进步和 Tan IIA 的治疗潜力，这两个方面的融合可以预见在临床应用中有很大的前景。
