Hashemian Mohammad Naser, Ghafarian Sadegh, Riazi-Esfahani Hamid, Khalili Pour Elias
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Curr Ophthalmol. 2023 Aug 11;35(1):36-41. doi: 10.4103/joco.joco_189_22. eCollection 2023 Jan-Mar.
To investigate the choroidal structure in keratoconic patients with different severity using the choroidal vascularity index (CVI) derived from image binarization on enhanced depth imaging optical coherence tomography scans (EDI-OCT).
Sixty-eight eyes from 34 keratoconus (KCN) patients and 72 eyes from 36 healthy subjects were recruited in this prospective, noninterventional, comparative cross-sectional study. EDI-OCT was employed to measure choroidal parameters, including choroidal thickness (CT), total choroidal area (TCA), luminal area, stromal area, and CVI.
Subfoveal CT was 354.6 ± 66.8 μm in the control group and 371 ± 64.5 μm in the KCN group ( = 0.86). There was no significant difference between control and KCN groups in terms of TCA (0.66 ± 0.14 mm vs. 0.7 ± 0.12 mm; = 0.70), luminal area (0.49 ± 0.10 mm vs. 0.53 ± 0.08 mm; = 0.67), and stromal area (0.16 ± 0.05 mm vs. 0.17 ± 0.05 mm; = 0.84). CVI was also comparable in the control group (75.4% ±3.4%) and the KCN group (75.6% ±4.5%; = 0.43). There was also no significant correlation between other choroidal parameters and KCN severity indices.
It seems that CVI as well as other choroidal biomarkers were not significantly different between patients with KCN and healthy subjects.
使用基于增强深度成像光学相干断层扫描（EDI-OCT）图像二值化得出的脉络膜血管指数（CVI），研究不同严重程度圆锥角膜患者的脉络膜结构。
本前瞻性、非干预性、对比性横断面研究纳入了34例圆锥角膜（KCN）患者的68只眼和36名健康受试者的72只眼。采用EDI-OCT测量脉络膜参数，包括脉络膜厚度（CT）、脉络膜总面积（TCA）、管腔面积、基质面积和CVI。
对照组中心凹下CT为354.6±66.8μm，KCN组为371±64.5μm（P=0.86）。对照组和KCN组在TCA（0.66±0.14mm对0.7±0.12mm；P=0.70）、管腔面积（0.49±0.10mm对0.53±0.08mm；P=0.67）和基质面积（0.16±0.05mm对0.17±0.05mm；P=0.84）方面无显著差异。CVI在对照组（75.4%±3.4%）和KCN组（75.6%±4.5%；P=0.43）中也具有可比性。其他脉络膜参数与KCN严重程度指数之间也无显著相关性。
KCN患者与健康受试者之间，CVI以及其他脉络膜生物标志物似乎无显著差异。
