Faisal Muhammad Salman, Sung Pamela J
Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Leuk Res Rep. 2023 Aug 27;20:100386. doi: 10.1016/j.lrr.2023.100386. eCollection 2023.
variants are frequently recurring in acute myeloid leukemia (AML). The prognostic significance of mutations has recently undergone a major shift in the 5th edition of WHO classification of hematological neoplasms and ELN 2022 classification. Whereas prior iterations did not specify the type of mutation, the updated schema specify that only mutations localized to the C-terminal basic zipper (bZIP) domain are considered prognostically favorable. This change is based primarily on three recently published large datasets evaluating the prognostic significance of mutation location in mutant AML. Here, we review the evolution of the prognostic classification of variants.
变异在急性髓系白血病（AML）中经常出现。在世界卫生组织血液肿瘤分类第5版和2022年欧洲白血病网络（ELN）分类中，突变的预后意义最近发生了重大转变。先前的版本未明确突变类型，而更新后的方案明确指出，只有定位于C端碱性拉链（bZIP）结构域的突变才被认为具有预后优势。这一变化主要基于最近发表的三个大型数据集，这些数据集评估了突变型AML中突变位置的预后意义。在此，我们回顾了变异预后分类的演变。
