van Charante Frits, Martínez-Pérez David, Guarch-Pérez Clara, Courtens Charlotte, Sass Andrea, Choińska Emilia, Idaszek Joanna, Van Calenbergh Serge, Riool Martijn, Zaat Sebastian A J, Święszkowski Wojciech, Coenye Tom
Laboratory of Pharmaceutical Microbiology, Ghent University, 9000 Ghent, Belgium.
Biomaterials, Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland.
iScience. 2023 Aug 7;26(9):107557. doi: 10.1016/j.isci.2023.107557. eCollection 2023 Sep 15.
causes a wide range of infections, including wound infections. Multidrug-resistant is a major healthcare concern and the development of novel treatments against these infections is needed. Fosmidomycin is a repurposed antimalarial drug targeting the non-mevalonate pathway, and several derivatives show activity toward . We evaluated the antimicrobial activity of CC366, a fosmidomycin prodrug, against a collection of strains, using various and models; emphasis was placed on the evaluation of its anti-biofilm activity. We also developed a 3D-printed wound dressing containing CC366, using melt electrowriting technology. Minimal inhibitory concentrations of CC366 ranged from 1 to 64 μg/mL, and CC366 showed good biofilm inhibitory and moderate biofilm eradicating activity . CC366 successfully eluted from a 3D-printed dressing, the dressings prevented the formation of wound biofilms and reduced infection in an mouse model.
会引发多种感染，包括伤口感染。多重耐药是一个重大的医疗保健问题，因此需要开发针对这些感染的新型治疗方法。磷霉素是一种重新利用的抗疟药物，靶向非甲羟戊酸途径，其几种衍生物对……显示出活性。我们使用各种……和……模型评估了磷霉素前药CC366对一系列……菌株的抗菌活性；重点评估了其抗生物膜活性。我们还利用熔体静电纺丝技术开发了一种含有CC366的3D打印伤口敷料。CC366的最低抑菌浓度范围为1至64μg/mL，并且CC366显示出良好的生物膜抑制和中等的生物膜消除活性……。CC366成功地从3D打印敷料中洗脱，该敷料可防止伤口生物膜的形成，并在……小鼠模型中减少了……感染。
