Molecular Bacteriology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.
Microbiology Laboratory, Department of Biology, Academic Areas, Federal Institute of Goiás, Anápolis, Goiás, Brazil.
Curr Drug Targets. 2024;25(14):971-986. doi: 10.2174/0113894501319269240819060245.
is a globally disseminated Gram-negative bacterium that causes several types of serious nosocomial infections, the most worrisome being ventilator-associated pneumonia and bacteremia related to using venous catheters. Due to its great ability to form biofilms, combined with its survival for prolonged periods on abiotic surfaces and its potential to acquire and control the genes that determine antibiotic resistance, is at the top of the World Health Organization's priority list of pathogens in urgent need of new therapies. In this sense, this review aimed to present and discuss new molecular targets present in A. baumannii with potential for promising treatment approaches. This review highlights crucial molecular targets, including cell division proteins, membrane synthesis enzymes, and biofilm-associated components, offering promising targets for novel antimicrobial drug development against infections.
鲍曼不动杆菌是一种广泛传播的革兰氏阴性菌，可引起多种严重的医院获得性感染，最令人担忧的是与使用静脉导管相关的呼吸机相关性肺炎和菌血症。由于其形成生物膜的巨大能力，加上其在非生物表面上长时间存活的能力，以及获得和控制决定抗生素耐药性的基因的能力，鲍曼不动杆菌被世界卫生组织列为急需新疗法的病原体优先级之首。从这个意义上说，本综述旨在介绍和讨论鲍曼不动杆菌中具有潜在有前途治疗方法的新分子靶标。本综述重点介绍了关键的分子靶标，包括细胞分裂蛋白、膜合成酶和生物膜相关成分，为针对鲍曼不动杆菌感染的新型抗菌药物的开发提供了有希望的靶标。
