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先天性肾积水合并尿路感染时的短暂性高血压

Transient hypertension with urinary tract infection in congenital hydronephrosis.

作者信息

Fukayama Haruka, Nakao Hiro, Nishi Kentaro, Kubota Mitsuru, Ishiguro Akira

机构信息

MD, National Center for Child Health and Development, Department of General Pediatrics & Interdisciplinary Medicine, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan, and National Center for Child Health and Development, Center for Postgraduate Education and Training, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.

MD, National Center for Child Health and Development, Center for Postgraduate Education and Training, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.

出版信息

Germs. 2022 Sep 30;12(3):400-403. doi: 10.18683/germs.2022.1344. eCollection 2022 Sep.

Abstract

INTRODUCTION

Hypertension is occasionally associated with congenital hydronephrosis.

CASE REPORT

The authors report a four-month-old boy with severe left congenital hydronephrosis and transient hypertension triggered by his first urinary tract infection (UTI). Despite the satisfactory UTI clinical course, he suddenly developed severe hypertension (130/80 mmHg) on the ninth day of UTI. His aldosterone level was within the reference range and his plasma renin activity was slightly elevated. Although his hypertension was refractory to calcium channel blockers, an angiotensin-converting enzyme inhibitor was effective for hypertension. On day 24, he was able to discontinue the antihypertensive without organ damage.

CONCLUSIONS

Although the precise cause of hypertension was unclear in our case, we considered it to be temporary renin-associated hypertension due to decreasing renal blood flow due to UTI in a patient with severe congenital hydronephrosis. In pediatric UTI, particularly in patients with unilateral hydronephrosis, blood pressure monitoring is very important.

摘要

引言

高血压偶尔与先天性肾积水相关。

病例报告

作者报告了一名4个月大的男孩,患有严重的左侧先天性肾积水,并因首次尿路感染(UTI)引发了短暂性高血压。尽管尿路感染的临床过程令人满意,但在尿路感染的第9天,他突然出现严重高血压(130/80 mmHg)。他的醛固酮水平在参考范围内,血浆肾素活性略有升高。尽管他的高血压对钙通道阻滞剂无效,但一种血管紧张素转换酶抑制剂对高血压有效。在第24天,他能够停用抗高血压药物且未出现器官损伤。

结论

尽管在我们的病例中高血压的确切原因尚不清楚,但我们认为这是由于严重先天性肾积水患者因尿路感染导致肾血流量减少而引起的暂时性肾素相关性高血压。在小儿尿路感染中,尤其是单侧肾积水患者,血压监测非常重要。

相似文献

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本文引用的文献

3
Causal link between neonatal hydronephrosis and later development of hypertension.新生儿肾积水与后期高血压之间的因果关系。
Clin Exp Pharmacol Physiol. 2010 Feb;37(2):e14-23. doi: 10.1111/j.1440-1681.2009.05267.x. Epub 2009 Aug 4.
6
Curable hypertension with unilateral hydronephrosis. Studies on the role of circulating renin.
Ann Intern Med. 1977 Oct;87(4):437-40. doi: 10.7326/0003-4819-87-4-437.

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