Wildgrube H J, Ostrowski J, Chamberlain J, Gärtner W, Stockhausen H
Arzneimittelforschung. 1986 Jul;36(7):1129-33.
Plasma levels of N-carboxy-3-morpholinosydnonimine ethyl ester (molsidomine, Corvaton) and its pharmacologically active metabolite 3-morpholinosydnonimine (SIN-1) were measured in six healthy male and female volunteers after single intravenous and oral dosing of 4 mg molsidomine. Additionally indocyanine green and phenazone (antipyrine) clearances were determined to estimate hepatic blood flow and metabolic liver function in each subject. The pharmacokinetic parameters of molsidomine were similar to already published data in healthy volunteers and patients. The plasma level of SIN-1 formed was always lower than the molsidomine level but obviously reflects the corresponding molsidomine concentration time course in plasma. Indocyanine green plasma clearance was reduced by 15%. after intravenous dosing of 4 mg molsidomine. There was no clear-cut relationship between the plasma clearances of molsidomine and phenazone in these subjects with normal metabolic liver function.
在6名健康男性和女性志愿者单次静脉注射和口服4毫克吗多明（N-羧基-3-吗啉代亚胺乙酯，商品名：可洛多昔）后，测定了血浆中吗多明及其药理活性代谢物3-吗啉代亚胺（SIN-1）的水平。此外，还测定了吲哚菁绿和非那宗（安替比林）清除率，以评估每个受试者的肝血流量和肝脏代谢功能。吗多明的药代动力学参数与健康志愿者和患者中已发表的数据相似。所形成的SIN-1血浆水平始终低于吗多明水平，但明显反映了血浆中相应的吗多明浓度-时间过程。静脉注射4毫克吗多明后，吲哚菁绿血浆清除率降低了15%。在这些肝脏代谢功能正常的受试者中，吗多明和非那宗的血浆清除率之间没有明确的关系。
