Department of Epidemiology and Biostatistics, School of Public Health, Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Medical Research Council Population Health Research Unit at the University of Oxford.
J Hypertens. 2023 Nov 1;41(11):1802-1810. doi: 10.1097/HJH.0000000000003549. Epub 2023 Sep 6.
Wide brachial pulse pressure (PP) has been associated with cardiovascular events, while its population distribution and association with body composition were poorly characterized in large populations.
We evaluated the age and sex distributions of PP and its associations with body composition using baseline data from the China Kadoorie Biobank. A total of 434 200 participants without diagnosed hypertension were included in the analysis. Wide PP was defined as PP above 65 mmHg. Body composition variables, including BMI, waist circumference, waist-to-hip ratio (WHR), fat mass index (FMI), fat-free mass index (FFMI), and body fat percentage (BF%), were obtained from bioelectrical impedance analysis.
Overall, 14.3% of the participants had wide PP. Older age was consistently associated with wider PP in women but only after the andropause stage in men. The independent associations of BMI with wide PP were stronger than other body composition measures. The adjusted differences (men/women, mmHg) in PP per standard deviation (SD) increase in BMI (1.55/1.47) were higher than other body composition (BF%: 0.32/0.64, waist circumference: 0.33/0.39; WHR: 0.49/0.42). In addition, sex differences were observed. In men, the per SD difference in PP was higher for FFMI than for FMI (0.91 vs. 0.67, P < 0.05), whereas in women, it was higher for FMI than for FFMI (1.01 vs. 0.72, P < 0.05).
Our nationwide population-based study presented the sex-specific distribution of PP over age and identified differential associations of PP with fat and fat-free mass in men and women.
宽脉压（PP）与心血管事件有关，但其在大人群中的分布情况及其与身体成分的关系尚未得到充分描述。
我们利用中国慢性病前瞻性研究（CKB）的基线数据，评估了 PP 的年龄和性别分布及其与身体成分的关系。共纳入 434200 名无高血压诊断的参与者进行分析。宽脉压定义为 PP 超过 65mmHg。身体成分变量包括 BMI、腰围、腰臀比（WHR）、脂肪质量指数（FMI）、去脂体重指数（FFMI）和体脂百分比（BF%），通过生物电阻抗分析获得。
总体而言，14.3%的参与者存在宽脉压。女性的年龄越大，脉压越宽，但仅在男性进入更年期后才出现这种情况。与宽脉压相关的 BMI 独立关联强于其他身体成分指标。与 BMI 每标准偏差（SD）增加 1 个单位相关的 PP 差值（男性/女性，mmHg）高于其他身体成分（BF%：0.32/0.64，腰围：0.33/0.39；WHR：0.49/0.42）。此外，还观察到了性别差异。在男性中，FFMI 每 SD 差异的 PP 高于 FMI（0.91 比 0.67，P<0.05），而在女性中，FMI 的 PP 高于 FFMI（1.01 比 0.72，P<0.05）。
本全国性基于人群的研究呈现了 PP 在年龄上的性别特异性分布，并确定了 PP 与男性和女性体内脂肪和去脂体重的不同关联。
