声门型癌症的转录亚型以典型致癌程序的差异激活为特征。
Transcriptional subtypes of glottic cancer characterized by differential activation of canonical oncogenic programming.
机构信息
Department of Otolaryngology - Head and Neck Surgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Birmingham Veteran Affairs Health Care System, Birmingham, Alabama, USA.
出版信息
Head Neck. 2023 Nov;45(11):2851-2861. doi: 10.1002/hed.27514. Epub 2023 Sep 8.
BACKGROUND
There is a paucity of data concerning molecular heterogeneity among glottic squamous cell carcinoma, and the clinical implications thereof.
METHODS
Data corresponding to glottic squamous cell carcinoma were derived from The Cancer Genome Atlas. The Onco-GPS computational methodology was levied to derive four patterns of transcriptional activity and three functional subtypes of glottic cancer.
RESULTS
Thirty glottic cancer samples stratified to three distinct oncogenic states (S0-S2) based on a Onco-GPS model containing four transcriptional components (F0-F3). Membership in S2 and association with transcriptional component F0 conveyed an invasive phenotype, with transcriptional activity strongly reflecting EMT programming (including TGF-B and NF-KB signaling). S2 membership also correlated with inferior disease-specific survival (HR 9.027, 95% CI 1.021-79.767), and higher incidences of extracapsular spread and perineural invasion.
CONCLUSIONS
We present a functional taxonomy of glottic cancer, with subtypes demonstrating differential upregulation of canonical oncogenic networks and survival implications.
背景
关于声门鳞状细胞癌的分子异质性及其临床意义的数据较少。
方法
来自癌症基因组图谱的声门鳞状细胞癌数据。利用 Onco-GPS 计算方法得出四种转录活性模式和三种声门癌功能亚型。
结果
根据包含四个转录成分（F0-F3）的 Onco-GPS 模型，30 个声门癌样本分为三个不同的致癌状态（S0-S2）。S2 成员和与转录成分 F0 的关联具有侵袭表型，转录活性强烈反映 EMT 编程（包括 TGF-β和 NF-κB 信号）。S2 成员还与较差的疾病特异性生存相关（HR 9.027，95%CI 1.021-79.767），以及更高的包膜外扩散和神经周围侵犯发生率。
结论
我们提出了一种声门癌的功能分类法，其亚型表现出经典致癌网络的差异上调和生存意义。
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