Institute of Discrete Mathematics and Geometry, Technische Universität Wien, Vienna, Austria.
Department of Theoretical Chemistry, University of Vienna, Vienna, Austria.
Bioinformatics. 2023 Sep 2;39(9). doi: 10.1093/bioinformatics/btad555.
Understanding RNA folding at the level of secondary structures can give important insights concerning the function of a molecule. We are interested to learn how secondary structures change dynamically during transcription, as well as whether particular secondary structures form already during or only after transcription. While different approaches exist to simulate cotranscriptional folding, the current strategies for visualization are lagging behind. New, more suitable approaches are necessary to help with exploring the generated data from cotranscriptional folding simulations.
We present DrForna, an interactive visualization app for viewing the time course of a cotranscriptional RNA folding simulation. Specifically, users can scroll along the time axis and see the population of structures that are present at any particular time point.
DrForna is a JavaScript project available on Github at https://github.com/ViennaRNA/drforna and deployed at https://viennarna.github.io/drforna.
理解 RNA 二级结构的折叠可以提供有关分子功能的重要见解。我们有兴趣了解二级结构在转录过程中如何动态变化，以及特定的二级结构是否在转录过程中或仅在转录后形成。虽然存在不同的方法来模拟共转录折叠，但可视化的当前策略却落后了。需要新的、更合适的方法来帮助探索共转录折叠模拟生成的数据。
我们介绍了 DrForna，这是一个用于查看共转录 RNA 折叠模拟时间进程的交互式可视化应用程序。具体来说，用户可以沿着时间轴滚动，并查看在任何特定时间点存在的结构的种群。
DrForna 是一个在 Github 上可用的 JavaScript 项目，网址为 https://github.com/ViennaRNA/drforna，并部署在 https://viennarna.github.io/drforna。
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