Department of Neurology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Radiology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Medicine (Baltimore). 2023 Sep 8;102(36):e35003. doi: 10.1097/MD.0000000000035003.
This study aimed to investigate the relationship between white matter hyperintensity (WMH) and cerebral microbleeds (CMBs) using susceptibility-weighted imaging (SWI) with high resolution. Additionally, it sought to analyze the clinical significance of SWI with high resolution and its potential to guide intravenous thrombolysis in stroke patients. In this retrospective analysis, we examined 96 patients with hypertension after acute stroke in our hospital using SWI. Demographic and medical data of these 96 patients were collected. Spearman correlation analysis was performed to investigate the relationship between CMBs and the grading of WMH. A significant positive correlation was observed between CMBs and the grade of WMH (R = 0.593, P < .05). The data also revealed a superior ROC area under the curve for the modified Fazekas grading of WMH, which was 0.814 (P < .05). There is a positive correlation between CMBs and the grading of leukoaraiosis in patients with acute stroke and hypertension. The higher the degree of WMH, the more severe the microvascular lesions, increasing the likelihood of intracranial hemorrhage. SWI can provide valuable guidance for administering intravenous thrombolysis in patients with acute stroke.
本研究旨在使用高分辨率磁敏感加权成像（SWI）来探究脑白质高信号（WMH）和脑微出血（CMBs）之间的关系。此外，还分析了高分辨率 SWI 的临床意义及其在指导急性脑卒中患者静脉溶栓中的潜在价值。在这项回顾性分析中，我们使用 SWI 检查了我院 96 例急性脑卒中后高血压患者。收集了这些 96 例患者的人口统计学和医学数据。采用 Spearman 相关性分析来探讨 CMBs 与 WMH 分级之间的关系。CMBs 与 WMH 分级之间存在显著正相关（R=0.593，P<.05）。数据还显示，WMH 的改良 Fazekas 分级的 ROC 曲线下面积为 0.814（P<.05）。在急性脑卒中合并高血压患者中，CMBs 与脑白质疏松症的分级呈正相关。WMH 程度越高，微血管病变越严重，颅内出血的可能性越大。SWI 可为急性脑卒中患者静脉溶栓治疗提供有价值的指导。
