Joint Reconstruction Research Center, Orthopedic Surgery Department, Imam Khomeini Hospital, Tehran, Iran.
JBJS Rev. 2023 Sep 8;11(9). doi: 10.2106/JBJS.RVW.23.00082. eCollection 2023 Sep 1.
» Genicular artery embolization (GAE) is a promising treatment option for patients with knee osteoarthritis who are unresponsive to nonsurgical treatments and not yet candidates for surgery.» Current evidence supports the effectiveness of GAE in reducing pain and synovitis, with few reported major adverse events.» The cost-effectiveness and long-term results of GAE compared with other treatment options require further investigation.» Limitations of existing studies include small sample sizes, single-center trials, and lack of comparison between embolic agents and other treatments.» Future research should focus on larger, multicenter trials with longer follow-up periods and head-to-head comparisons with alternative treatment modalities to establish the role of GAE in the management of knee osteoarthritis.
» 膝关节动脉栓塞术（GAE）是一种有前途的治疗选择，适用于对非手术治疗无反应且尚未适合手术的膝关节骨关节炎患者。» 当前的证据支持 GAE 在减轻疼痛和滑膜炎方面的有效性，且报告的重大不良事件较少。» GAE 与其他治疗选择相比的成本效益和长期结果需要进一步研究。» 现有研究的局限性包括样本量小、单中心试验以及栓塞剂与其他治疗方法之间缺乏比较。» 未来的研究应侧重于更大规模、多中心的试验，随访时间更长，并与替代治疗方式进行头对头比较，以确定 GAE 在膝关节骨关节炎治疗中的作用。
