Hsu Chou-Yi, Allela Omer Qutaiba B, Mahdi Sheereehan Adull-Hussein, Doshi Ojas Prakashbhai, Adil Mohaned, Ali Mohammed Shnain, Saadh Mohamed J
Department of Pharmacy, Chia Nan University of Pharmacy and Science, Taiwan.
Department of Pharmacy, Al-Noor University College, Nineveh, Iraq.
Pathol Res Pract. 2023 Oct;250:154794. doi: 10.1016/j.prp.2023.154794. Epub 2023 Sep 3.
MiRNAs have emerged as crucial modulators of the expression of their target genes, attracting significant attention due to their engagement in various cellular processes, like cancer onset and development. Amidst the extensive repertoire of miRNAs implicated in cancer, miR-136-5p has emerged as an emerging miRNA with diverse roles. Dysregulation of miR-136-5p has been proved in human cancers. Accumulating evidence suggests that miR-136-5p mainly functions as a tumor suppressor. These data proposed that miR-136-5p is engaged in the regulation of various cellular processes, like cell proliferation, migration, invasion, EMT, and apoptosis. In addition, miR-136-5p has demonstrated substantial potential as a prognostic and diagnostic marker in human cancers as well as an effective mediator in cancer chemotherapy. Furthermore, miR-136-5p was shown to be correlated with clinicopathological features of affected patients, proposing that it could be used for cancer staging and patient survival. Therefore, a comprehensive comprehension of the precise molecular basis governing miR-136-5p dysregulation in different cancers is vital for unraveling its therapeutic importance. Here, we have discussed the molecular basis of miR-136-5p as a potential tumor suppressor as well as its importance in cancer diagnosis, prognosis, and chemotherapy. Finally, we have discussed the challenge of using miRNAs as a therapeutic target as well as the prospect regarding the importance of miR-136-5p in human cancers.
微小RNA（miRNAs）已成为其靶基因表达的关键调节因子，由于它们参与各种细胞过程，如癌症的发生和发展，因此备受关注。在与癌症相关的众多miRNAs中，miR-136-5p已成为一种具有多种作用的新兴miRNA。miR-136-5p的失调已在人类癌症中得到证实。越来越多的证据表明，miR-136-5p主要起肿瘤抑制作用。这些数据表明，miR-136-5p参与调节各种细胞过程，如细胞增殖、迁移、侵袭、上皮-间质转化（EMT）和凋亡。此外，miR-136-5p在人类癌症中已显示出作为预后和诊断标志物的巨大潜力，以及在癌症化疗中作为有效介质的潜力。此外，miR-136-5p与受影响患者的临床病理特征相关，这表明它可用于癌症分期和患者生存评估。因此，全面了解不同癌症中miR-136-5p失调的精确分子基础对于阐明其治疗重要性至关重要。在这里，我们讨论了miR-136-5p作为潜在肿瘤抑制因子的分子基础及其在癌症诊断、预后和化疗中的重要性。最后，我们讨论了将miRNAs用作治疗靶点的挑战以及miR-136-5p在人类癌症中的重要性的前景。
