Hsu Hui-Ting, Lu Yen-Ting, Chen Yi-Tzu, Hsing Ming-Tai, Su Chun-Wen, Su Shih-Chi, Lin Chiao-Wen, Yang Shun-Fa
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
School of Medicine, China Medical University, Taichung, Taiwan.
J Cancer. 2024 Mar 4;15(8):2354-2360. doi: 10.7150/jca.94187. eCollection 2024.
Oral squamous cell carcinoma (OSCC) is a prevalent and lethal malignancy with a diverse etiology. LINC00312 is a long intergenic non-coding RNA that functions as a signal hub to regulate the progression and treatment of head and neck cancer. The aim of this study was to evaluate the effect of single nucleotide polymorphisms (SNPs) on the development of oral cancer. Two SNPs, namely rs12497104 and rs164966, were investigated among 469 male patients with cancer of buccal mucosa and 1194 gender- and age-matched controls. No significant correlation was observed between these two SNPs and the occurrence of OSCC in the case and control groups. While assessing the clinicopathological features, carriers of at least one minor allele of rs164966 (GA and GG) were less prone to develop lymph node metastasis (adjusted odds ratio [AOR], 0.666; 95% confidence interval [CI], 0.447-0.991; =0.045) in comparison with homozygous carriers of the major allele (AA). Subsequent stratifying surveys revealed that this genetic association with nodal spread was seen only in cases who habitually chewed betel quid (AOR, 0.616; 95% CI, 0.386-0.985; =0.042) or smoked cigarettes (AOR, 0.612; 95% CI, 0.393-0.953; =0.029), but undetected in cases free of these main behavioral risks. Our results indicate an interactivity of rs164966 with lifestyle-related risks on modulating OSCC progression.
口腔鳞状细胞癌（OSCC）是一种常见且致命的恶性肿瘤，病因多样。LINC00312是一种长链基因间非编码RNA，作为信号枢纽调节头颈癌的进展和治疗。本研究旨在评估单核苷酸多态性（SNP）对口腔癌发生发展的影响。在469例颊黏膜癌男性患者和1194例性别及年龄匹配的对照中，对两个SNP，即rs12497104和rs164966进行了研究。在病例组和对照组中，未观察到这两个SNP与OSCC发生之间存在显著相关性。在评估临床病理特征时，与主要等位基因纯合子（AA）相比，rs164966至少携带一个次要等位基因（GA和GG）的携带者发生淋巴结转移的可能性较小（调整优势比[AOR]，0.666；95%置信区间[CI]，0.447 - 0.991；P = 0.045）。随后的分层调查显示，这种与淋巴结扩散的遗传关联仅在习惯性嚼槟榔（AOR，0.616；95% CI，0.386 - 0.985；P = 0.042）或吸烟（AOR，0.612；95% CI，0.393 - 0.953；P = 0.029）的患者中观察到，而在没有这些主要行为风险的患者中未检测到。我们的结果表明rs164966与生活方式相关风险在调节OSCC进展方面存在相互作用。
