Service of Anesthesiology, Universitary Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
Service of Anesthesiology, Universitary Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
Rev Esp Anestesiol Reanim (Engl Ed). 2024 Apr;71(4):298-303. doi: 10.1016/j.redare.2022.06.009. Epub 2023 Sep 7.
Opioids are still the drugs of choice for the treatment of acute post-surgical pain and chronic cancer pain. Overprescribing of these drugs has given rise to an "opioid crisis" in some countries. In this context, attention has been drawn to the therapeutic potential of various ligands that act as allosteric modulators of orthosteric binding sites and modulate the drug's activity, affinity, potency, and even efficacy.
阿片类药物仍然是治疗急性术后疼痛和慢性癌痛的首选药物。这些药物的过度处方导致一些国家出现了“阿片类药物危机”。在这种情况下，人们开始关注各种配体的治疗潜力，这些配体作为变构调节剂作用于正位结合位点，调节药物的活性、亲和力、效力，甚至疗效。
