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血清素信号在进化上不同的谱系中调节形态发生过程中的肌动球蛋白收缩。

Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages.

机构信息

Aix-Marseille Université & CNRS, IBDM-UMR7288 & Turing Centre for Living Systems, Marseille, France.

Collège de France, Paris, France.

出版信息

Nat Commun. 2023 Sep 8;14(1):5547. doi: 10.1038/s41467-023-41178-w.

DOI:10.1038/s41467-023-41178-w
PMID:37684231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10491668/
Abstract

Serotonin is a neurotransmitter that signals through 5-HT receptors to control key functions in the nervous system. Serotonin receptors are also ubiquitously expressed in various organs and have been detected in embryos of different organisms. Potential morphogenetic functions of serotonin signaling have been proposed based on pharmacological studies but a mechanistic understanding is still lacking. Here, we uncover a role of serotonin signaling in axis extension of Drosophila embryos by regulating Myosin II (MyoII) activation, cell contractility and cell intercalation. We find that serotonin and serotonin receptors 5HT2A and 5HT2B form a signaling module that quantitatively regulates the amplitude of planar polarized MyoII contractility specified by Toll receptors and the GPCR Cirl. Remarkably, serotonin signaling also regulates actomyosin contractility at cell junctions, cellular flows and epiblast morphogenesis during chicken gastrulation. This phylogenetically conserved mechanical function of serotonin signaling in regulating actomyosin contractility and tissue flow reveals an ancestral role in morphogenesis of multicellular organisms.

摘要

血清素是一种神经递质，通过 5-HT 受体传递信号，控制神经系统的关键功能。血清素受体也广泛表达于各种器官中，并在不同生物体的胚胎中被检测到。基于药理学研究，提出了血清素信号传递的潜在形态发生功能，但对其机制仍缺乏了解。在这里，我们通过调节肌球蛋白 II（MyoII）激活、细胞收缩和细胞插入，揭示了血清素信号在果蝇胚胎轴延伸中的作用。我们发现，血清素和血清素受体 5HT2A 和 5HT2B 形成了一个信号模块，定量调节 Toll 受体和 GPCR Cirl 所指定的平面极化 MyoII 收缩的幅度。值得注意的是，血清素信号还调节着鸡胚形成过程中细胞连接处、细胞流动和上皮层形态发生的肌动球蛋白收缩。这种在调节肌动球蛋白收缩和组织流动方面的血清素信号的系统发生保守的机械功能，揭示了其在多细胞生物形态发生中的古老作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/cd95410a9527/41467_2023_41178_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/6480e45d18ed/41467_2023_41178_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/2a2fa2ce152a/41467_2023_41178_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/53533270648f/41467_2023_41178_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/1e6fe4a31be1/41467_2023_41178_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/50bb857bc321/41467_2023_41178_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/cd95410a9527/41467_2023_41178_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/6480e45d18ed/41467_2023_41178_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/2a2fa2ce152a/41467_2023_41178_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/53533270648f/41467_2023_41178_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/1e6fe4a31be1/41467_2023_41178_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/50bb857bc321/41467_2023_41178_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e564/10491668/cd95410a9527/41467_2023_41178_Fig6_HTML.jpg

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