Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México. Mexico City, Mexico.
Departamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología, Mexico.
Reprod Biol. 2021 Mar;21(1):100475. doi: 10.1016/j.repbio.2020.100475. Epub 2020 Dec 25.
Since its discovery in 1937, serotonin (5-HT) has become one of the most studied biogenic amines due to its predominant role in regulating several physiological processes such as mood, sleep, and food intake. This amine and the main components of the serotoninergic system are in almost all cells of the body. The presence of 5-HT and the serotoninergic system has been observed in oocytes and in different embryo development stages of fish, amphibians, birds, and mammals. In several classes of vertebrates, the change in the concentration of 5-HT or the alteration of the serotoninergic system, interfere with early embryo development. These data suggest that 5-HT participates in embryo development of vertebrates.
自 1937 年发现以来，由于其在调节情绪、睡眠和食欲等多种生理过程中的主要作用，血清素（5-HT）已成为研究最多的生物胺之一。这种胺和血清素能系统的主要成分几乎存在于体内所有细胞中。在卵子和鱼类、两栖动物、鸟类和哺乳动物的不同胚胎发育阶段都观察到了 5-HT 和血清素能系统的存在。在几类脊椎动物中，5-HT 浓度的变化或血清素能系统的改变，会干扰早期胚胎发育。这些数据表明，5-HT 参与了脊椎动物的胚胎发育。
