Department of Gastroenterology, Wuhan No.1 Hospital, Wuhan, China.
Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Sci Rep. 2023 Sep 8;13(1):14812. doi: 10.1038/s41598-023-41596-2.
Our aim was to explore the correlation between ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) based on FibroTouch (China) and clinical features in patients with non-alcoholic fatty liver disease (NAFLD), so as to provide a certain basis for the clinical application of FibroTouch in NAFLD. Hepatic steatosis and fibrosis in patients with NAFLD were graded according to FibroTouch, and the relationship between steatosis and fibrosis levels and clinical characteristics was retrospectively analyzed. Hepatic steatosis was positively related with weight, BMI, waist, hyperlipidemia, hyperuricemia, FBG, UA, TG, ALT, AST, GGT, LSM and hepatic fibrosis grading, and was negatively related with gender (male), age and AST/ALT ratio. Hepatic fibrosis was positively related with age, BMI, waist, hypertension, FBG, ALT, AST, GGT, NFS, APRI, FIB-4, UAP and hepatic steatosis grading, and was negatively related with blood platelet (PLT) counts. Moreover, BMI, waist, TG, ALT and LSM were independent risk factors of hepatic steatosis, while decreased PLT counts, AST and UAP were independent risk factors of hepatic fibrosis. Body mass parameters, metabolic risk factors and liver function indicators increase the risk of hepatic steatosis and fibrosis in patients with NAFLD, and UAP and LSM can interact with each other.
我们的目的是探讨基于 FibroTouch（中国）的超声衰减参数（UAP）与肝硬度测量（LSM）在非酒精性脂肪性肝病（NAFLD）患者中的相关性，并探讨其与临床特征的关系，为 FibroTouch 在 NAFLD 中的临床应用提供一定依据。根据 FibroTouch 对患者的肝脂肪变和肝纤维化程度进行分级，并对其与临床特征的关系进行回顾性分析。肝脂肪变与体重、BMI、腰围、高血脂、高尿酸血症、FBG、UA、TG、ALT、AST、GGT、LSM 和肝纤维化分级呈正相关，与性别（男）、年龄和 AST/ALT 比值呈负相关。肝纤维化与年龄、BMI、腰围、高血压、FBG、ALT、AST、GGT、NFS、APRI、FIB-4、UAP 和肝脂肪变分级呈正相关，与血小板（PLT）计数呈负相关。此外，BMI、腰围、TG、ALT 和 LSM 是肝脂肪变的独立危险因素，而 PLT 计数减少、AST 和 UAP 是肝纤维化的独立危险因素。体质量参数、代谢危险因素和肝功能指标增加了 NAFLD 患者肝脂肪变和纤维化的风险，且 UAP 和 LSM 可相互作用。
