Inamdar Arati A, Pulinthanathu Rajiv
Department of Pathology, RWJBarnabas Health, Livingston, NJ, USA.
Bladder (San Franc). 2019 Dec 26;6(2):e39. doi: 10.14440/bladder.2019.805. eCollection 2019.
Inflammatory myofibroblastic tumor (IMT) previously known as inflammatory pseudotumor, plasma cell granuloma, pseudosarcoma, myxoid hamartoma or inflammatory myofibrohistiocytic proliferation is recently recognized by World Health Organization (WHO) as "IMT" and is considered as a rare benign tumor of soft tissues occurring commonly in lung, liver and mesentry and omentum. IMT is mainly identified as a lesion of children and young population. In this report, we describe a rare case of IMT occurring in a 93-year-old female in urinary bladder with initial benign presentation but demonstrating rapid malignant transformation as confirmed with morphology and immunohistochemical (IHC) stains. Our report highlights the importance of close follow for IMT showing malignant transformation along with utility of IHC stains to evaluate the degree of malignant transformation in such cases.
炎性肌纤维母细胞瘤(IMT)以前被称为炎性假瘤、浆细胞肉芽肿、假肉瘤、黏液样错构瘤或炎性肌纤维组织细胞增生,最近被世界卫生组织(WHO)确认为“IMT”,并被认为是一种罕见的软组织良性肿瘤,常见于肺、肝、肠系膜和网膜。IMT主要被认定为儿童和青年人群的病变。在本报告中,我们描述了一例罕见的IMT病例,发生在一名93岁女性的膀胱中,最初表现为良性,但经形态学和免疫组织化学(IHC)染色证实显示出快速的恶性转化。我们的报告强调了对显示恶性转化的IMT进行密切随访的重要性,以及IHC染色在评估此类病例恶性转化程度方面的实用性。