Obrzut Marzanna, Atamaniuk Vitaliy, Ehman Richard L, Yin Meng, Cholewa Marian, Gutkowski Krzysztof, Domka Wojciech, Ozga Dorota, Obrzut Bogdan
Institute of Health Sciences, Medical College, University of Rzeszow, Warzywna 1a, 35-310 Rzeszow, Poland.
Department of Biophysics, Institute of Physics, College of Natural Sciences, University of Rzeszow, Prof. Stanisława Pigonia Str. 1, 35-310 Rzeszow, Poland.
Diagnostics (Basel). 2023 Aug 23;13(17):2738. doi: 10.3390/diagnostics13172738.
Magnetic resonance elastography (MRE) has been established as the most accurate noninvasive technique for diagnosing liver fibrosis. Recent publications have suggested that the measurement of splenic stiffness is useful in setting where portal hypertension may be present. The goal of the current study was to compile normative data for MRE-assessed stiffness measurements of the spleen in young adults.
A total of 100 healthy young Caucasian volunteers (65 females and 35 males) in the age range of 20 to 32 years were enrolled in this study. The participants reported no history of chronic spleen and liver disease, normal alcohol consumption, and a normal diet. The MRE data were acquired by using a 1.5 T whole-body scanner and a 2D GRE pulse sequence with 60 Hz excitation. Spleen stiffness was calculated as a weighted mean of stiffness values in the regions of interest manually drawn by the radiologist on three to five spleen slices.
Mean spleen stiffness was 5.09 ± 0.65 kPa for the whole group. Male volunteers had slightly higher splenic stiffness compared to females: 5.28 ± 0.78 vs. 4.98 ± 0.51 kPa, however, this difference was not statistically significant ( = 0.12). Spleen stiffness did not correlate with spleen fat content and liver stiffness but a statistically significant correlation with spleen volume was found.
The findings of this study provide normative values for 2D MRE-based measurement of spleen stiffness in young adults, a basis for assessing the value of this biomarker in young patients with portal system pathologies.
磁共振弹性成像（MRE）已被确立为诊断肝纤维化最准确的非侵入性技术。最近的出版物表明，脾硬度测量在可能存在门静脉高压的情况下是有用的。本研究的目的是汇编年轻成年人中通过MRE评估的脾脏硬度测量的标准数据。
本研究共纳入100名年龄在20至32岁之间的健康年轻白种人志愿者（65名女性和35名男性）。参与者无慢性脾脏和肝脏疾病史，酒精摄入量正常，饮食正常。使用1.5T全身扫描仪和具有60Hz激发的二维梯度回波（GRE）脉冲序列采集MRE数据。脾脏硬度通过放射科医生在三到五张脾脏切片上手动绘制的感兴趣区域的硬度值的加权平均值来计算。
整个组的平均脾脏硬度为5.09±0.65kPa。男性志愿者的脾脏硬度略高于女性：5.28±0.78 vs. 4.98±0.51kPa，然而，这种差异无统计学意义（P = 0.12）。脾脏硬度与脾脏脂肪含量和肝脏硬度无关，但与脾脏体积存在统计学显著相关性。
本研究结果为基于二维MRE的年轻成年人脾脏硬度测量提供了标准值，为评估该生物标志物在门静脉系统病变年轻患者中的价值奠定了基础。
