Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Abdom Radiol (NY). 2022 Sep;47(9):3028-3036. doi: 10.1007/s00261-022-03597-z. Epub 2022 Jul 19.
In 1995, a vivid image of diffracting waves in red and blue was published on the cover of the journal SCIENCE. An article in that issue described a new imaging technology called magnetic resonance elastography (MRE) (Muthupillai in Science 269:1854-1857, 1995). In 2004, quantitative images of liver stiffness in vivo, obtained with MRE, were demonstrated for the first time at the annual meeting of the International Society for Magnetic Resonance in Medicine. Only five years later, the technology had become widely available as an FDA-cleared diagnostic tool for patient care. MRE has emerged as a reliable non-invasive diagnostic method for detecting and staging liver fibrosis. Deployed on more than 2000 MRI systems worldwide, MRE has received a Category I CPT code from the American Medical Association, based on clinical availability and efficacy. For many patients, MRE now provides a safe, more comfortable, and much less expensive alternative to liver biopsy for diagnosing liver fibrosis. Although progress in radiology is notable for a history of very rapid translation of technology innovations to patient care, the path is rarely linear. This article reflects on the story of MRE, the advances and the setbacks, and the lessons that were learned in the process.
1995 年，一篇发表在《科学》杂志封面上的文章生动地展示了红蓝相间的衍射波。该期杂志中的一篇文章描述了一种名为磁共振弹性成像（MRE）的新技术（Muthupillai 在 Science 269:1854-1857, 1995）。2004 年，在国际磁共振医学学会年会上首次展示了 MRE 获得的活体肝脏硬度定量图像。仅仅五年后，该技术已成为获得 FDA 批准的用于患者护理的诊断工具而广泛应用。MRE 已成为一种可靠的无创性诊断方法，可用于检测和分期肝纤维化。在全球 2000 多台 MRI 系统上部署，MRE 已获得美国医学协会的 I 类 CPT 代码，这是基于其临床可用性和疗效。对于许多患者来说，MRE 现在为诊断肝纤维化提供了一种安全、更舒适、更便宜的替代肝活检的方法。尽管放射学领域的进展显著，因为技术创新迅速转化为患者护理，但道路很少是线性的。本文回顾了 MRE 的故事，包括进展和挫折，以及在这个过程中吸取的教训。
