Obrzut Marzanna, Atamaniuk Vitaliy, Ehman Richard L, Yin Meng, Cholewa Marian, Gutkowski Krzysztof, Domka Wojciech, Obrzut Bogdan
Institute of Health Sciences, Medical College, University of Rzeszow, Rzeszow, Poland.
Department of Biophysics, College of Natural Sciences, Institute of Physics, University of Rzeszow, Rzeszow, Poland.
NMR Biomed. 2024 Feb;37(2):e5047. doi: 10.1002/nbm.5047. Epub 2023 Oct 9.
Magnetic resonance elastography (MRE) is an accurate noninvasive diagnostic tool for assessing the stiffness of parenchymal organs, including the spleen. However, this measurement may be biased due to postprandial changes in splenic stiffness. The aim of the current study was to evaluate postprandial changes in spleen stiffness assessed by MRE in a large sample of healthy volunteers. This was a prospective institutional research ethics board-approved study. Healthy volunteers with no history of liver disease were recruited for an MRE test and blood draw from December 2018 to July 2019. Each participant underwent spleen MRE after at least 4 h of fasting and again 30 min after a 1000 kcal meal. Also, 14 randomly selected volunteers underwent additional MRE examinations at 1.5 and 2.5 h after food intake. The MRE data were acquired at 60 Hz using a 1.5-T MRI scanner. The spleen stiffness was assessed using a weighted mean of stiffness values from regions of interest manually drawn on three to five spleen slices. Spearman's rank correlation, Wilcoxon signed-rank, Friedman, and Mann-Whitney tests were used for statistical analysis. A total of 100 volunteers met the inclusion criteria and were eventually enrolled in this study (age 23 ± 2 years; 65 women). The mean spleen stiffness for the whole group increased by 7.9% (p < 0.001) from the mean ± SD value of 5.09 ± 0.63 (95% CI: 4.96-5.21) kPa in the fasting state to 5.47 ± 0.66 (95% CI 5.34-5.60) kPa 30 min after the meal and then gradually decreased. However, even 2 h 30 min after the meal, the spleen stiffness was higher than in the fasting state. This difference was statistically significant at p less than 0.001. It was concluded that meal intake results in a statistically significant elevation of spleen stiffness that persists for 2.5 h. This finding supports the recommendation for routine fasting for more than 2.5 h prior to assessing MRE-based spleen stiffness.
磁共振弹性成像（MRE）是一种准确的非侵入性诊断工具，用于评估包括脾脏在内的实质器官的硬度。然而，由于餐后脾脏硬度的变化，这种测量可能存在偏差。本研究的目的是在大量健康志愿者样本中评估MRE评估的餐后脾脏硬度变化。这是一项经机构研究伦理委员会批准的前瞻性研究。招募无肝脏疾病史的健康志愿者进行MRE检查和采血，时间为2018年12月至2019年7月。每位参与者在禁食至少4小时后进行脾脏MRE检查，并在进食1000千卡餐后30分钟再次进行检查。此外，14名随机选择的志愿者在进食后1.5小时和2.5小时接受了额外的MRE检查。使用1.5-T MRI扫描仪以60Hz采集MRE数据。脾脏硬度通过在三到五张脾脏切片上手动绘制的感兴趣区域的硬度值的加权平均值进行评估。采用Spearman秩相关、Wilcoxon符号秩、Friedman和Mann-Whitney检验进行统计分析。共有100名志愿者符合纳入标准并最终纳入本研究（年龄23±2岁；65名女性）。整个组的平均脾脏硬度从禁食状态下的平均±标准差5.09±0.63（95%CI：4.96-5.21）kPa增加了7.9%（p<0.001），至餐后30分钟的5.47±0.66（95%CI 5.34-5.60）kPa，然后逐渐下降。然而，即使在餐后2小时30分钟，脾脏硬度仍高于禁食状态。这种差异在p小于0.001时具有统计学意义。得出的结论是，进食导致脾脏硬度在统计学上显著升高，并持续2.5小时。这一发现支持了在评估基于MRE的脾脏硬度之前常规禁食超过2.5小时的建议。
