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采用菱形镜折射法的用于手术荧光显微镜的高强度宽光束单准对称发光二极管

Single Quasi-Symmetrical LED with High Intensity and Wide Beam Width Using Diamond-Shaped Mirror Refraction Method for Surgical Fluorescence Microscope Applications.

作者信息

Ju Minki, Yoon Kicheol, Lee Sangyun, Kim Kwang Gi

机构信息

Medical Devices R&D Center, Gachon University Gil Medical Center, 21, 774 beon-gil, Namdong-daero Namdong-gu, Incheon 21565, Republic of Korea.

Department of Biomedical Engineering, College of Health Science & Medicine, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Republic of Korea.

出版信息

Diagnostics (Basel). 2023 Aug 25;13(17):2763. doi: 10.3390/diagnostics13172763.

DOI:10.3390/diagnostics13172763
PMID:37685301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10486995/
Abstract

To remove tumors with the same blood vessel color, observation is performed using a surgical microscope through fluorescent staining. Therefore, surgical microscopes use light emitting diode (LED) emission and excitation wavelengths to induce fluorescence emission wavelengths. LEDs used in hand-held type microscopes have a beam irradiation range of 10° and a weak power of less than 0.5 mW. Therefore, fluorescence emission is difficult. This study proposes to increase the beam width and power of LED by utilizing the quasi-symmetrical beam irradiation method. Commercial LED irradiates a beam 1/r distance away from the target (working distance). To obtain the fluorescence emission probability, set up four mirrors. The distance between the mirrors and the LED is 5.9 cm, and the distance between the mirrors and the target is 2.95 cm. The commercial LED reached power on target of 8.0 pW within the wavelength band of 405 nm. The power reaching the target is 0.60 mW in the wavelength band of 405 nm for the LED with the beam mirror attachment method using the quasi-symmetrical beam irradiation method. This result is expected to be sufficient for fluorescence emission. The light power of the mirror was increased by approximately four times.

摘要

为了切除具有相同血管颜色的肿瘤，通过荧光染色使用手术显微镜进行观察。因此，手术显微镜利用发光二极管（LED）的发射和激发波长来诱导荧光发射波长。手持式显微镜中使用的LED的光束照射范围为10°，功率小于0.5 mW，较弱。因此，荧光发射困难。本研究提出利用准对称光束照射方法增加LED的光束宽度和功率。商用LED在距离目标（工作距离）1/r处照射光束。为了获得荧光发射概率，设置了四面镜子。镜子与LED之间的距离为5.9 cm，镜子与目标之间的距离为2.95 cm。商用LED在405 nm波长带内到达目标的功率为8.0 pW。对于采用准对称光束照射方法的带光束镜附件方法的LED，在405 nm波长带内到达目标的功率为0.60 mW。该结果预计足以实现荧光发射。镜子的光功率增加了约四倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/0fe059772953/diagnostics-13-02763-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/eb8b1bc83092/diagnostics-13-02763-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/384fea8c0092/diagnostics-13-02763-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/2009365c391e/diagnostics-13-02763-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/e349fcc8fb64/diagnostics-13-02763-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/71c7cc096dd8/diagnostics-13-02763-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/290d50c6191b/diagnostics-13-02763-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/63f3499ec024/diagnostics-13-02763-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/63d492e78d9a/diagnostics-13-02763-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/0fe059772953/diagnostics-13-02763-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/eb8b1bc83092/diagnostics-13-02763-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/384fea8c0092/diagnostics-13-02763-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/2009365c391e/diagnostics-13-02763-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/e349fcc8fb64/diagnostics-13-02763-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/71c7cc096dd8/diagnostics-13-02763-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/290d50c6191b/diagnostics-13-02763-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/63f3499ec024/diagnostics-13-02763-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/63d492e78d9a/diagnostics-13-02763-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6284/10486995/0fe059772953/diagnostics-13-02763-g009.jpg

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