Rescues Allergic Contact Dermatitis in Sphingosine 1-Phosphate Receptor 2-Deficient Skin.

Recent studies have identified a subtype of the S1P-receptor family called sphingosine-1-phosphate receptor 2 (S1PR2), which plays a crucial role in maintaining the skin barrier. It has been observed that S1PR2 and () work together to regulate the skin barrier. However, the interaction between these two factors is still unclear. To investigate this, a study was conducted on healthy skin and allergic contact dermatitis (ACD) using 3,4-Dibutoxy-3-cyclobutene-1,2-dione (SADBE) on the ears of and mice and using 1 × 10 CFU of to examine its effects on the skin. The results showed that in -conditioned ACD, the ear thickness of mice was lower than that of mice, and mRNA expressions of and of mice were lower than that of mice in ACD with . Furthermore, the gene expression of and in mice was higher than that of mice in ACD with . The study concludes that colonization improves the skin barrier and prevents ACD even when S1P signaling malfunctions.