Department of Dermatology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Int J Mol Sci. 2023 Aug 25;24(17):13190. doi: 10.3390/ijms241713190.
Recent studies have identified a subtype of the S1P-receptor family called sphingosine-1-phosphate receptor 2 (S1PR2), which plays a crucial role in maintaining the skin barrier. It has been observed that S1PR2 and () work together to regulate the skin barrier. However, the interaction between these two factors is still unclear. To investigate this, a study was conducted on healthy skin and allergic contact dermatitis (ACD) using 3,4-Dibutoxy-3-cyclobutene-1,2-dione (SADBE) on the ears of and mice and using 1 × 10 CFU of to examine its effects on the skin. The results showed that in -conditioned ACD, the ear thickness of mice was lower than that of mice, and mRNA expressions of and of mice were lower than that of mice in ACD with . Furthermore, the gene expression of and in mice was higher than that of mice in ACD with . The study concludes that colonization improves the skin barrier and prevents ACD even when S1P signaling malfunctions.
最近的研究已经确定了 S1P 受体家族的一个亚型，称为鞘氨醇-1-磷酸受体 2（S1PR2），它在维持皮肤屏障中起着至关重要的作用。已经观察到 S1PR2 和 （）共同作用以调节皮肤屏障。然而，这两个因素之间的相互作用尚不清楚。为了研究这一点，在健康皮肤和过敏性接触性皮炎（ACD）中进行了一项研究，使用 3,4-二丁氧基-3-环丁烯-1,2-二酮（SADBE）在 和 小鼠的耳朵上，并用 1×10 CFU 的 来检查其对皮肤的影响。结果表明，在 条件下的 ACD 中， 小鼠的耳朵厚度低于 小鼠，而在 SADBE 诱导的 ACD 中， 小鼠的 和 基因的 mRNA 表达低于 小鼠。此外，在 ACD 中， 小鼠的 和 基因的表达高于 小鼠。研究得出结论，定植可改善皮肤屏障，并可预防即使 S1P 信号传导功能障碍也会导致的 ACD。
