Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Int J Mol Sci. 2023 Aug 28;24(17):13312. doi: 10.3390/ijms241713312.
Oral squamous cell carcinoma (OSCC) is a prevalent form of malignant tumor, characterized by a persistently high incidence and mortality rate. The extracellular matrix (ECM) plays a crucial role in the initiation, progression, and diverse biological behaviors of OSCC, facilitated by mechanisms such as providing structural support, promoting cell migration and invasion, regulating cell morphology, and modulating signal transduction. This study investigated the involvement of ECM-related genes, particularly , in the prognosis and cellular behavior of OSCC. The analysis of ECM-related gene data from OSCC samples identified 165 differentially expressed genes forming two clusters with distinct prognostic outcomes. Seventeen ECM-related genes showed a significant correlation with survival. Experimental methods were employed to demonstrate the impact of on proliferation, migration, invasion, and ECM degradation in OSCC cells. A risk-prediction model utilizing four differentially prognostic genes demonstrated significant predictive value in overall survival. exhibited enrichment of the PI3K/AKT pathway, indicating its potential role in modulating OSCC. In conclusion, this study observed and verified that ECM-related genes, particularly , have the potential to influence the prognosis, biological behavior, and immunotherapy of OSCC. These findings hold significant implications for enhancing survival outcomes and providing guidance for precise treatment of OSCC.
口腔鳞状细胞癌（OSCC）是一种常见的恶性肿瘤，其发病率和死亡率一直居高不下。细胞外基质（ECM）在 OSCC 的发生、发展和多种生物学行为中起着至关重要的作用，其机制包括提供结构支持、促进细胞迁移和侵袭、调节细胞形态以及调节信号转导等。本研究探讨了细胞外基质相关基因，特别是 ，在 OSCC 预后和细胞行为中的作用。对 OSCC 样本中细胞外基质相关基因数据的分析确定了 165 个差异表达基因，这些基因形成了两个具有不同预后结果的簇。17 个细胞外基质相关基因与生存显著相关。实验方法证明了 在 OSCC 细胞增殖、迁移、侵袭和细胞外基质降解中的作用。利用四个具有不同预后的基因构建的风险预测模型在总生存率方面表现出显著的预测价值。 表现出 PI3K/AKT 通路的富集，表明其在调节 OSCC 方面的潜在作用。总之，本研究观察并验证了细胞外基质相关基因，特别是 ，有可能影响 OSCC 的预后、生物学行为和免疫治疗。这些发现对提高生存结果和为 OSCC 的精确治疗提供指导具有重要意义。
