Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, I-00133 Rome, Italy.
Int J Mol Sci. 2023 Aug 28;24(17):13344. doi: 10.3390/ijms241713344.
Phytoestrogens are plant-derived bioactive compounds with estrogen-like properties. Their potential health benefits, especially in cancer prevention and treatment, have been a subject of considerable research in the past decade. Phytoestrogens exert their effects, at least in part, through interactions with estrogen receptors (ERs), mimicking or inhibiting the actions of natural estrogens. Recently, there has been growing interest in exploring the impact of phytoestrogens on osteosarcoma (OS), a type of bone malignancy that primarily affects children and young adults and is currently presenting limited treatment options. Considering the critical role of the estrogen/ERs axis in bone development and growth, the modulation of ERs has emerged as a highly promising approach in the treatment of OS. This review provides an extensive overview of current literature on the effects of phytoestrogens on human OS models. It delves into the multiple mechanisms through which these molecules regulate the cell cycle, apoptosis, and key pathways implicated in the growth and progression of OS, including ER signaling. Moreover, potential interactions between phytoestrogens and conventional chemotherapy agents commonly used in OS treatment will be examined. Understanding the impact of these compounds in OS holds great promise for developing novel therapeutic approaches that can augment current OS treatment modalities.
植物雌激素是具有类雌激素特性的植物源性生物活性化合物。在过去十年中，它们在预防和治疗癌症方面的潜在健康益处一直是相当多研究的主题。植物雌激素通过与雌激素受体 (ER) 的相互作用发挥作用，至少部分模拟或抑制天然雌激素的作用。最近，人们越来越关注植物雌激素对骨肉瘤 (OS) 的影响，骨肉瘤是一种主要影响儿童和青少年的骨恶性肿瘤，目前治疗选择有限。考虑到雌激素/ERs 轴在骨骼发育和生长中的关键作用，ERs 的调节已成为 OS 治疗中极具前景的方法。本综述提供了关于植物雌激素对人类 OS 模型影响的广泛文献综述。它深入探讨了这些分子调节细胞周期、细胞凋亡以及与 OS 生长和进展相关的关键途径（包括 ER 信号转导）的多种机制。此外，还将研究植物雌激素与骨肉瘤常用的常规化疗药物之间的潜在相互作用。了解这些化合物在 OS 中的作用，为开发新的治疗方法提供了很大的希望，可以增强目前 OS 的治疗方式。
