Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Int J Mol Sci. 2023 Aug 28;24(17):13355. doi: 10.3390/ijms241713355.
This investigation demonstrates the use of dimethyl fumarate (DMF) for the treatment of disseminated granuloma annulare (GAD), a rare and chronic inflammatory skin disease. In this case, progressive GAD was treated with DMF, resulting in significant improvement of skin lesions within 5 weeks and complete healing within 7 months. Clinical response was associated with a reduction in inflammatory cells, including both T cell subsets (CD4+ > CD8+), CD183/CXCR3 cells, Langerhans cells (CD1a+), myeloid DCs, M1- and M2-like macrophages and the activation marker HLA-DR in immunohistochemical analysis. These findings support the use of DMF as a promising treatment option for this rare skin condition.
本研究展示了富马酸二甲酯（DMF）在治疗播散性环状肉芽肿（GAD）中的应用，GAD 是一种罕见的慢性炎症性皮肤病。在该病例中，DMF 治疗进行性 GAD，5 周内皮肤病变显著改善，7 个月内完全愈合。临床反应与炎症细胞的减少相关，包括 T 细胞亚群（CD4+ > CD8+）、CD183/CXCR3 细胞、朗格汉斯细胞（CD1a+）、髓样树突状细胞、M1 样和 M2 样巨噬细胞以及免疫组化分析中的激活标志物 HLA-DR。这些发现支持 DMF 作为一种有前途的治疗选择，用于这种罕见的皮肤疾病。
