Spindler Michael, Berneburg Mark, Drexler Konstantin, Kurz Bernadett, Kögel Julian, Niebel Dennis
Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
Dermatologie (Heidelb). 2025 Jan;76(1):27-33. doi: 10.1007/s00105-024-05436-2. Epub 2024 Dec 18.
Granuloma annulare (GA) is a noninfectious, granulomatous dermatosis that is generally localized and self-limiting. In 15% of cases, the disease disseminates with protracted trajectories. This study aims to characterise the patient population with disseminated GA at a German university hospital and to explore treatment modalities.
A retrospective monocentric evaluation was conducted at the University Hospital Regensburg between 2021 and 2023 with descriptive statistical analysis of the patient population and the treatment modalities used.
During the specified period, 239 patients with GA were identified, 33 of whom had histologically confirmed disseminated GA. Of the patients, 25 (76%) were women. Average age was 57.4 ± 14.4 years. Furthermore 17 patients (53%) denied symptoms. Common symptoms included dysesthesia, itching and pain. Frequent concomitant diseases were diabetes mellitus, thyroid disease, atopic dermatitis and coronary heart disease. Topical glucocorticoids, systemic glucocorticoids, phototherapy, topical calcineurin inhibitors and dimethyl fumarate were used therapeutically in descending frequency. Only 6 patients (18%) showed partial or complete remission.
Due to the lack of approved therapies, disseminated GA is treated with inadequately effective regimens. Prospective randomized placebo-controlled trials are needed to investigate the efficacy of novel targeted therapies.
环状肉芽肿（GA）是一种非感染性肉芽肿性皮肤病，通常呈局限性且具有自限性。在15%的病例中，该病会呈迁延性播散。本研究旨在对德国一家大学医院中播散性GA患者群体进行特征描述，并探索治疗方式。
2021年至2023年期间在雷根斯堡大学医院进行了一项回顾性单中心评估，对患者群体及所采用的治疗方式进行描述性统计分析。
在规定期间内，共识别出239例GA患者，其中33例经组织学证实为播散性GA。患者中25例（76%）为女性。平均年龄为57.4±14.4岁。此外，17例患者（53%）否认有症状。常见症状包括感觉异常、瘙痒和疼痛。常见的伴发疾病有糖尿病、甲状腺疾病、特应性皮炎和冠心病。治疗上使用频率由高到低依次为外用糖皮质激素、系统糖皮质激素、光疗、外用钙调神经磷酸酶抑制剂和富马酸二甲酯。只有6例患者（18%）显示部分或完全缓解。
由于缺乏获批的治疗方法，播散性GA采用的治疗方案效果欠佳。需要进行前瞻性随机安慰剂对照试验来研究新型靶向治疗的疗效。
