Eberlein-König B, Mempel M, Stahlecker J, Forer I, Ring J, Abeck D
Division Environmental Dermatology and Allergology GSF/TUM, Neuherberg-Munich, Germany.
Dermatology. 2005;210(3):223-6. doi: 10.1159/000083514.
The therapy of disseminated granuloma annulare has often limited success. Treatment of granuloma annulare with fumaric acid esters (FAE) has recently been reported to be effective in 2 patients.
To assess the efficacy of a systemic therapy with FAE in consecutive patients with disseminated granuloma annulare.
Eight patients with disseminated granuloma annulare were treated with FAE in tablet form according to the standard therapy regimen used in psoriasis. The colour and the elevation of the skin lesions were assessed by a visual analogue scale before and after therapy.
Systemic therapy with FAE induced a significant clinical improvement in elevation and colour of skin lesions, with remission in 3 and partial remission in 4 patients. One patient remained unchanged. Side-effects associated with the therapy were seen in 6 patients.
Systemic therapy with FAE can be effective in patients suffering from disseminated forms of granuloma annulare, but side-effects of FAE have to be taken into consideration.
播散性环状肉芽肿的治疗效果往往有限。最近有报道称，用富马酸酯（FAE）治疗环状肉芽肿在2例患者中有效。
评估采用FAE进行系统治疗对连续性播散性环状肉芽肿患者的疗效。
8例播散性环状肉芽肿患者按照银屑病的标准治疗方案，采用片剂形式的FAE进行治疗。在治疗前后，通过视觉模拟量表评估皮肤损害的颜色和隆起程度。
采用FAE进行系统治疗后，皮肤损害的隆起程度和颜色有显著临床改善，3例患者缓解，4例患者部分缓解。1例患者无变化。6例患者出现与治疗相关的副作用。
采用FAE进行系统治疗对患有播散性环状肉芽肿的患者可能有效，但必须考虑FAE的副作用。
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