Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
Division of Endoscopy, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
Int J Mol Sci. 2023 Aug 30;24(17):13470. doi: 10.3390/ijms241713470.
The association between liver fibrosis and oral or gut microbiota has been studied before. However, epidemiological studies in the general population are limited owing to the difficulty of noninvasive liver-fibrosis assessment. FibroScan-asparate aminotransferase (FAST) scores can be used to accurately and non-invasively evaluate liver fibrosis. This study aimed to determine the association between liver fibrosis and oral or gut microbiota using the FAST score in the general population. After propensity score matching of 1059 participants based on sex, age, body mass index, homeostasis model assessment of insulin resistance, and triglyceride levels, 125 (non-liver-fibrosis group, 100; liver fibrosis group, 25) were included. The diversity of gut microbiota differed significantly between the two groups; however, no significant differences were noted in their oral microbiota. The liver fibrosis group showed an increase in the relative abundance of strains and a decrease in the relative abundance of , with the presence of in the gut microbiota. was not identified as an independent factor of liver fibrosis in adjusting the fatty liver index. In the general population, gut microbiota may be more involved in liver fibrosis than oral microbiota.
先前已有研究探讨了肝纤维化与口腔或肠道微生物群之间的关联。然而，由于非侵入性肝纤维化评估存在困难，一般人群中的流行病学研究受到限制。纤维扫描-天冬氨酸转氨酶（FAST）评分可用于准确、非侵入性地评估肝纤维化。本研究旨在使用 FAST 评分在一般人群中确定肝纤维化与口腔或肠道微生物群之间的关联。在基于性别、年龄、体重指数、胰岛素抵抗稳态模型评估和甘油三酯水平对 1059 名参与者进行倾向评分匹配后，125 名（非肝纤维化组 100 名，肝纤维化组 25 名）被纳入研究。两组之间肠道微生物群的多样性差异显著，但口腔微生物群无显著差异。肝纤维化组的 菌株相对丰度增加， 菌株相对丰度减少， 菌株存在于肠道微生物群中。 未被确定为调整脂肪肝指数的肝纤维化的独立因素。在一般人群中，肠道微生物群可能比口腔微生物群更多地参与肝纤维化。
