Clinical Laboratory Unit, IRCCS "Bambino Gesù" Children's Hospital, 00165 Rome, Italy.
Research Area of Management Innovations, Diagnostics and Clinical Pathways, IRCCS "Bambino Gesù" Children's Hospital, 00165 Rome, Italy.
Nutrients. 2023 Aug 25;15(17):3717. doi: 10.3390/nu15173717.
Childhood overweight and obesity have been described by the World Health Organization as noncommunicable diseases and among the greatest public health threats since they have reached epidemic proportions. A child with obesity risks becoming an adult with obesity and developing metabolic and hemostatic disorders which are the basis for the development of coronary heart diseases. Recently, a number of clinical reports have demonstrated that both an increase in plasminogen activator inhibitor-1 (PAI-1) and a deficiency in 25OH-vitamin D3 (VD) are associated with an increase in thrombotic episodes.
PAI-1 and VD levels were measured in 259 clinically overweight and obese children aged between 2 and 18 years enrolled in the Nutritional Education Program of the Bambino Gesù Children's Hospital and Research Institute of Rome (Italy) and 80 normal-weight subjects.
We observed increased HOMA-IR, PAI-1, and other inflammation indices associated with decreased VD levels when compared to normal-weight children.
Our results demonstrated that overweight and obesity are correlated with higher levels of the inflammation index. Moreover, our patients show high PAI-1 and low VD levels, confirming the high thrombotic risk in our pediatric population.
世界卫生组织将儿童超重和肥胖描述为非传染性疾病，是最大的公共卫生威胁之一，因为它们已经达到了流行的程度。肥胖儿童有发展为肥胖成年人的风险，并可能出现代谢和止血紊乱，这是冠心病发展的基础。最近，一些临床报告表明，纤溶酶原激活物抑制剂-1（PAI-1）的增加和 25-羟维生素 D3（VD）的缺乏都与血栓形成事件的增加有关。
在罗马的 Bambino Gesù 儿童医院和研究所的营养教育计划中，我们测量了 259 名年龄在 2 至 18 岁的临床超重和肥胖儿童以及 80 名正常体重儿童的 PAI-1 和 VD 水平。
与正常体重儿童相比，我们观察到 HOMA-IR、PAI-1 和其他与 VD 水平降低相关的炎症指标增加。
我们的结果表明，超重和肥胖与更高的炎症指数有关。此外，我们的患者显示出较高的 PAI-1 和较低的 VD 水平，证实了我们儿科人群的高血栓形成风险。
